Next-generation cancer organoids

BL LeSavage, RA Suhar, N Broguiere, MP Lutolf… - Nature materials, 2022 - nature.com
Organotypic models of patient-specific tumours are revolutionizing our understanding of
cancer heterogeneity and its implications for personalized medicine. These advancements …

Hydrogels as drug delivery systems: A review of current characterization and evaluation techniques

M Vigata, C Meinert, DW Hutmacher, N Bock - Pharmaceutics, 2020 - mdpi.com
Owing to their tunable properties, controllable degradation, and ability to protect labile
drugs, hydrogels are increasingly investigated as local drug delivery systems. However, a …

Hydrogels for biomedical applications: their characteristics and the mechanisms behind them

Q Chai, Y Jiao, X Yu - Gels, 2017 - mdpi.com
Hydrogels are hydrophilic, three-dimensional networks that are able to absorb large
quantities of water or biological fluids, and thus have the potential to be used as prime …

Gelatin methacryloyl and its hydrogels with an exceptional degree of controllability and batch-to-batch consistency

M Zhu, Y Wang, G Ferracci, J Zheng, NJ Cho… - Scientific reports, 2019 - nature.com
Gelatin methacryloyl (GelMA) is a versatile material for a wide range of bioapplications.
There is an intense interest in developing effective chemical strategies to prepare GelMA …

Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip

YS Zhang, A Arneri, S Bersini, SR Shin, K Zhu… - Biomaterials, 2016 - Elsevier
Engineering cardiac tissues and organ models remains a great challenge due to the
hierarchical structure of the native myocardium. The need of integrating blood vessels brings …

Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels

K Yue, G Trujillo-de Santiago, MM Alvarez, A Tamayol… - Biomaterials, 2015 - Elsevier
Gelatin methacryloyl (GelMA) hydrogels have been widely used for various biomedical
applications due to their suitable biological properties and tunable physical characteristics …

Gelatin-methacryloyl (GelMA) hydrogels with defined degree of functionalization as a versatile toolkit for 3D cell culture and extrusion bioprinting

I Pepelanova, K Kruppa, T Scheper, A Lavrentieva - Bioengineering, 2018 - mdpi.com
Gelatin-methacryloyl (GelMA) is a semi-synthetic hydrogel which consists of gelatin
derivatized with methacrylamide and methacrylate groups. These hydrogels provide cells …

Functionalization, preparation and use of cell-laden gelatin methacryloyl–based hydrogels as modular tissue culture platforms

D Loessner, C Meinert, E Kaemmerer, LC Martine… - Nature protocols, 2016 - nature.com
Progress in advancing a system-level understanding of the complexity of human tissue
development and regeneration is hampered by a lack of biological model systems that …

Precise tuning of facile one-pot gelatin methacryloyl (GelMA) synthesis

H Shirahama, BH Lee, LP Tan, NJ Cho - Scientific reports, 2016 - nature.com
Gelatin-methacryloyl (GelMA) is one of the most commonly used photopolymerizable
biomaterials in bio-applications. However, GelMA synthesis remains suboptimal, as its …

Cranial suture regeneration mitigates skull and neurocognitive defects in craniosynostosis

M Yu, L Ma, Y Yuan, X Ye, A Montagne, J He, TV Ho… - Cell, 2021 - cell.com
Craniosynostosis results from premature fusion of the cranial suture (s), which contain
mesenchymal stem cells (MSCs) that are crucial for calvarial expansion in coordination with …