Pathogenic bacteria must withstand diverse host environments during infection.
Environmental signals, such as pH, temperature, nutrient limitation, etc., not only trigger …

The success of Salmonella as a foodborne pathogen can probably be attributed to two major
features: its remarkable genetic diversity and its extraordinary ability to adapt. Salmonella …

Detoxification, scavenging, and repair systems embody the archetypical antioxidant
defenses of prokaryotic and eukaryotic cells. Metabolic rewiring also aids with the …

Bacteria tightly regulate intracellular zinc levels to ensure sufficient zinc to support essential
functions, while preventing toxicity. The bacterial response to zinc limitation includes the …

Production of inorganic polyphosphate (polyP) by bacteria is triggered by a variety of
different stress conditions. polyP is required for stress survival and virulence in diverse …

The type III secretion system encoded in the Salmonella pathogenicity island-2 (SPI-2) gene
cluster facilitates intracellular growth of nontyphoidal Salmonella by interfering with the …

The redox conditions that reign inside a cell have a determining effect on a number of
biological processes. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) …

The adaptations that protect pathogenic microorganisms against the cytotoxicity of nitric
oxide (NO) engendered in the immune response are incompletely understood. We show …

RNA polymerase is the only known protein partner of the transcriptional regulator DksA.
Herein, we demonstrate that the chaperone DnaJ establishes direct, redox-based …

In the course of an infection, Salmonella enterica occupies diverse anatomical sites with
various concentrations of oxygen (O2) and nitric oxide (NO). These diatomic gases compete …