Being opportunistic intracellular pathogens, viruses are dependent on the host for their
replication. They hijack host cellular machinery for their replication and survival by targeting …

A harmonized balance between positive and negative regulation of pattern recognition
receptor (PRR)-initiated immune responses is required to achieve the most favorable …

The genomic binding sites of the transcription factor (TF) and tumor suppressor p53 are
unusually diverse with regard to their chromatin features, including histone modifications …

Inflammasome contributes to the pathogenesis of various inflammatory diseases, but the
epigenetic mechanism controlling its activation remains elusive. Here, we found that the …

Seven tumor necrosis factor receptor‐(TNFR‐) associated factors (TRAFs) have been found
in mammals, which are primarily involved in the signal translation of the TNFR superfamily …

SUMO modifications regulate the function of many proteins and are important in controlling
herpesvirus infections. We performed a site-specific proteomic analysis of SUMO1-and …

Ischemia-reperfusion injury (IRI) is an inevitable and serious clinical problem in donations
after heart death (DCD) liver transplantation. Excessive sterile inflammation plays a fateful …

African swine fever (ASF) is a highly contagious lethal viral disease in pigs caused by the
African swine fever virus (ASFV), which has greatly threatened Chinese animal health and …

Ovarian tumor domain-containing 6B (OTUD6B) belongs to the OTU deubiquitylating
enzyme family. In this study, we report that zebrafish otud6b is induced upon viral infection …

The tripartite motif (TRIM) family comprises at least 80 members in humans, with most
having ubiquitin or SUMO E3 ligase activity conferred by their N-terminal RING domain …