The heart is lined by a single layer of mesothelial cells called the epicardium that provides
important cellular contributions for embryonic heart formation. The epicardium harbors a …

Recent advances in cell tracing and sequencing technologies have expanded our
knowledge on leukocyte behavior. As a consequence, inflammatory cells, such as monocyte …

Rationale: Accurate knowledge of the cellular composition of the heart is essential to fully
understand the changes that occur during pathogenesis and to devise strategies for tissue …

Macrophages populate the healthy myocardium and, depending on their phenotype, may
contribute to tissue homeostasis or disease. Their origin and role in diastolic dysfunction, a …

Background: Cardiac fibrosis is a key antecedent to many types of cardiac dysfunction
including heart failure. Physiological factors leading to cardiac fibrosis have been …

In response to myocardial infarction (MI), cardiac macrophages regulate inflammation and
scar formation. We hypothesized that macrophages undergo polarization state changes over …

Aging is accompanied by the functional decline of tissues. However, a systematic study of
epigenomic and transcriptomic changes across tissues during aging is missing. Here, we …

Macrophages are integral components of cardiac tissue and exert profound effects on the
healthy and diseased heart. Paradigm shifting studies using advanced molecular …

The mammalian heart contains a population of resident macrophages that expands in
response to myocardial infarction and hemodynamic stress. This expansion occurs likely …

Background: DNA methylation is implicated in coronary heart disease (CHD), but current
evidence is based on small, cross-sectional studies. We examined blood DNA methylation …