Regeneration of skeletal system with genipin crosslinked biomaterials
Z Wang, H Liu, W Luo, T Cai, Z Li… - Journal of Tissue …, 2020 - journals.sagepub.com
Natural biomaterials, such as collagen, gelatin, and chitosan, are considered as promising
candidates for use in tissue regeneration treatment, given their similarity to natural tissues …
candidates for use in tissue regeneration treatment, given their similarity to natural tissues …
Advanced models of human skeletal muscle differentiation, development and disease: Three-dimensional cultures, organoids and beyond
S Jalal, S Dastidar, FS Tedesco - Current opinion in cell biology, 2021 - Elsevier
Advanced in vitro models of human skeletal muscle tissue are increasingly needed to model
complex developmental dynamics and disease mechanisms not recapitulated in animal …
complex developmental dynamics and disease mechanisms not recapitulated in animal …
[HTML][HTML] Actuated tissue engineered muscle grafts restore functional mobility after volumetric muscle loss
Damage that affects large volumes of skeletal muscle tissue can severely impact health,
mobility, and quality-of-life. Efforts to restore muscle function by implanting tissue …
mobility, and quality-of-life. Efforts to restore muscle function by implanting tissue …
The mini-IDLE 3D biomimetic culture assay enables interrogation of mechanisms governing muscle stem cell quiescence and niche repopulation
Adult skeletal muscle harbours a population of muscle stem cells (MuSCs) that are required
for repair after tissue injury. In youth, MuSCs return to a reversible state of cell-cycle arrest …
for repair after tissue injury. In youth, MuSCs return to a reversible state of cell-cycle arrest …
Methionine adenosyltransferase2A inhibition restores metabolism to improve regenerative capacity and strength of aged skeletal muscle
We investigate the age-related metabolic changes that occur in aged and rejuvenated
myoblasts using in vitro and in vivo models of aging. Metabolic and signaling experiments …
myoblasts using in vitro and in vivo models of aging. Metabolic and signaling experiments …
Bioengineered human skeletal muscle capable of functional regeneration
Abstract Background Skeletal muscle (SkM) regenerates following injury, replacing
damaged tissue with high fidelity. However, in serious injuries, non-regenerative defects …
damaged tissue with high fidelity. However, in serious injuries, non-regenerative defects …
Bioengineered 3D skeletal muscle model reveals complement 4b as a cell‐autonomous mechanism of impaired regeneration with aging
A mechanistic understanding of cell‐autonomous skeletal muscle changes after injury can
lead to novel interventions to improve functional recovery in an aged population. However …
lead to novel interventions to improve functional recovery in an aged population. However …
[HTML][HTML] Experimental models as a tool for research on sarcopenia: A narrative review
J Alonso-Puyo, O Izagirre-Fernandez, O Crende… - Ageing Research …, 2024 - Elsevier
Sarcopenia is a musculoskeletal disorder related to muscle mass and function; as the
worldwide population ages, its growing prevalence means a decline in quality of life and an …
worldwide population ages, its growing prevalence means a decline in quality of life and an …
Reversine ameliorates hallmarks of cellular senescence in human skeletal myoblasts via reactivation of autophagy
Cellular senescence leads to the depletion of myogenic progenitors and decreased
regenerative capacity. We show that the small molecule 2, 6‐disubstituted purine, reversine …
regenerative capacity. We show that the small molecule 2, 6‐disubstituted purine, reversine …
Myoblast deactivation within engineered human skeletal muscle creates a transcriptionally heterogeneous population of quiescent satellite-like cells
J Wang, T Broer, T Chavez, CJ Zhou, S Tran, Y Xiang… - Biomaterials, 2022 - Elsevier
Satellite cells (SCs), the adult Pax7-expressing stem cells of skeletal muscle, are essential
for muscle repair. However, in vitro investigations of SC function are challenging due to …
for muscle repair. However, in vitro investigations of SC function are challenging due to …