Tissue regeneration following injury from disease or medical treatment still represents a
challenge in regeneration medicine. Prostaglandin E2 (PGE2), which involves diverse …

Prostaglandins (PGs) are the major lipid mediators in animals and which are biosynthesized
from arachidonic acid by the cyclooxygenases (COX-1 or COX-2) as the rate-limiting …

PUFAs, such as AA and DHA, are recognized as important biomolecules, but understanding
their precise roles and modes of action remains challenging. PUFAs are precursors for a …

Frizzleds (Fzd) are the primary receptors for Wnt morphogens, which are essential
regulators of stem cell biology, yet the structural basis of Wnt signaling through Fzd remains …

The lipid prostaglandin E2 (PGE2) mediates inflammatory pain by activating G protein-
coupled receptors, including the prostaglandin E2 receptor 4 (EP4R). Nonsteroidal anti …

Adrenergic receptors are G protein-coupled receptors for epinephrine and norepinephrine.
They are targets of many drugs for various conditions, including treatment of hypertension …

Immune checkpoint blockade (ICB) has a limited effect on colorectal cancer, underlining the
requirement of co‐targeting the complementary mechanisms. Here, we identified …

The CC motif chemokine receptor 8 (CCR8) is a class A G-protein coupled receptor that has
emerged as a promising therapeutic target in cancer. Targeting CCR8 with an antibody has …

Melatonin receptors (MT1 and MT2) transduce inhibitory signaling by melatonin (N-acetyl-5-
methoxytryptamine), which is associated with sleep induction and circadian rhythm …

Ghrelin is a gastric peptide hormone with important physiological functions. The unique
feature of ghrelin is its Serine 3 acyl-modification, which is essential for ghrelin's activity …