Background Methodological research to evaluate the performance of methods requires a
benchmark to serve as a referent comparison. In drug safety, the performance of analyses of …

Background Uncertainty remains about the optimal monotherapy for hypertension, with
current guidelines recommending any primary agent among the first-line drug classes …

ACE (angiotensin-converting enzyme) inhibitors and angiotensin receptor blockers (ARBs)
are equally guideline-recommended first-line treatments for hypertension, yet few head-to …

Introduction: With increasing availability, the use of healthcare databases as complementary
data source for drug safety signal detection has been explored to circumvent the limitations …

Importance Chlorthalidone is currently recommended as the preferred thiazide diuretic to
treat hypertension, but no trials have directly compared risks and benefits. Objective To …

Background Propensity score adjustment is a popular approach for confounding control in
observational studies. Reliable frameworks are needed to determine relative propensity …

Objective Advances in standardization of observational healthcare data have enabled
methodological breakthroughs, rapid global collaboration, and generation of real-world …

Evidence for the effectiveness and safety of the third-generation β-blockers other than
atenolol in hypertension remains scarce. We assessed the effectiveness and safety of β …

Healthcare professionals increasingly rely on observational healthcare data, such as
administrative claims and electronic health records, to estimate the causal effects of …

Confounding remains one of the major challenges to causal inference with observational
data. This problem is paramount in medicine, where we would like to answer causal …