In vivo delivery of CRISPR-Cas9 genome editing components for therapeutic applications
Since its mechanism discovery in 2012 and the first application for mammalian genome
editing in 2013, CRISPR-Cas9 has revolutionized the genome engineering field and created …
editing in 2013, CRISPR-Cas9 has revolutionized the genome engineering field and created …
Overview of recent advances in nano-based ocular drug delivery
LC Liu, YH Chen, DW Lu - International Journal of Molecular Sciences, 2023 - mdpi.com
Ocular diseases profoundly impact patients' vision and overall quality of life globally.
However, effective ocular drug delivery presents formidable challenges within clinical …
However, effective ocular drug delivery presents formidable challenges within clinical …
Adeno-associated virus (AAV)-based gene therapies for retinal diseases: where are we?
Owing to their small size and safety profiles, adeno-associated viruses (AAVs) have become
the vector of choice for gene therapy applications in the retina. In addition to the naturally …
the vector of choice for gene therapy applications in the retina. In addition to the naturally …
Unleashing the potential of CRISPR multiplexing: Harnessing Cas12 and Cas13 for precise gene modulation in eye diseases
Gene therapy is a flourishing field with the potential to revolutionize the treatment of genetic
diseases. The emergence of CRISPR-Cas9 has significantly advanced targeted and efficient …
diseases. The emergence of CRISPR-Cas9 has significantly advanced targeted and efficient …
Biomaterials-mediated CRISPR/Cas9 delivery: recent challenges and opportunities in gene therapy
AK Dubey, E Mostafavi - Frontiers in Chemistry, 2023 - frontiersin.org
The use of biomaterials in delivering CRISPR/Cas9 for gene therapy in infectious diseases
holds tremendous potential. This innovative approach combines the advantages of …
holds tremendous potential. This innovative approach combines the advantages of …
Role of CRISPR/Cas9 in the treatment of Duchenne muscular dystrophy and its delivery strategies
Duchenne muscular dystrophy (DMD) is a neuromuscular disorder brought on by mutations
in the DMD gene, which prevent muscle cells from expressing the dystrophin protein …
in the DMD gene, which prevent muscle cells from expressing the dystrophin protein …
Future perspectives of prime editing for the treatment of inherited retinal diseases
Inherited retinal diseases (IRD) are a clinically and genetically heterogenous group of
diseases and a leading cause of blindness in the working-age population. Even though …
diseases and a leading cause of blindness in the working-age population. Even though …
[HTML][HTML] Recent advances in carbon monoxide-releasing nanomaterials
X Ning, X Zhu, Y Wang, J Yang - Bioactive Materials, 2024 - Elsevier
As an endogenous signaling molecule, carbon monoxide (CO) has emerged as an
increasingly promising option regarding as gas therapy due to its positive pharmacological …
increasingly promising option regarding as gas therapy due to its positive pharmacological …
AAV-based strategies for treatment of retinal and choroidal vascular diseases: advances in age-related macular degeneration and diabetic retinopathy therapies
Age-related macular degeneration (AMD) and diabetic retinopathy (DR) are vascular
diseases with high prevalence, ranking among the leading causes of blindness and vision …
diseases with high prevalence, ranking among the leading causes of blindness and vision …
Nanoplatform‐based in vivo gene delivery systems for cancer therapy
R Luo, H Le, Q Wu, C Gong - Small, 2024 - Wiley Online Library
Gene therapy uses modern molecular biology methods to repair disease‐causing genes. As
a burgeoning therapeutic, it has been widely applied for cancer therapy. Since 1989, there …
a burgeoning therapeutic, it has been widely applied for cancer therapy. Since 1989, there …