Recent advances in triterpenoid pathway elucidation and engineering

S Dinday, S Ghosh - Biotechnology Advances, 2023 - Elsevier
Triterpenoids are among the most assorted class of specialized metabolites found in all the
taxa of living organisms. Triterpenoids are the leading active ingredients sourced from plant …

Biosynthetic pathways of triterpenoids and strategies to improve their biosynthetic efficiency

HA Noushahi, AH Khan, UF Noushahi, M Hussain… - Plant Growth …, 2022 - Springer
Abstract “Triterpenoids” can be considered natural products derived from the cyclization of
squalene, yielding 3-deoxytriterpenes (hydrocarbons) or 3-hydroxytriterpenes. Triterpenoids …

Oleanane-, ursane-, and quinone methide friedelane-type triterpenoid derivatives: Recent advances in cancer treatment

JAR Salvador, AS Leal, AS Valdeira… - European Journal of …, 2017 - Elsevier
Natural pentacyclic triterpenoids (PTs) have been often reported to exhibit a wide range of
biological activities. Among them, the anticancer and anti-inflammatory activities are the …

Role of saponins in plant defense against specialist herbivores

M Hussain, B Debnath, M Qasim, BS Bamisile, W Islam… - Molecules, 2019 - mdpi.com
The diamondback moth (DBM), Plutella xylostella (Lepidoptera: Plutellidae) is a very
destructive crucifer-specialized pest that has resulted in significant crop losses worldwide …

Triterpene structural diversification by plant cytochrome P450 enzymes

S Ghosh - Frontiers in plant science, 2017 - frontiersin.org
Cytochrome P450 monooxygenases (P450s) represent the largest enzyme family of the
plant metabolism. Plants typically devote about 1% of the protein-coding genes for the …

Making small molecules in plants: a chassis for synthetic biology‐based production of plant natural products

X Liu, P Zhang, Q Zhao… - Journal of Integrative Plant …, 2023 - Wiley Online Library
Plant natural products have been extensively exploited in food, medicine, flavor, cosmetic,
renewable fuel, and other industrial sectors. Synthetic biology has recently emerged as a …

Antibacterial and antifungal terpenes from the medicinal angiosperms of Asia and the Pacific: Haystacks and gold needles

C Wiart, G Kathirvalu, CS Raju, V Nissapatorn… - Molecules, 2023 - mdpi.com
This review identifies terpenes isolated from the medicinal Angiosperms of Asia and the
Pacific with antibacterial and/or antifungal activities and analyses their distribution …

Research progress in steroidal saponins from the genus Polygonatum: chemical components, biosynthetic pathways and pharmacological effects

C Xu, B Xia, Z Zhang, Y Lin, C Li, L Lin - Phytochemistry, 2023 - Elsevier
Abstract The genus Polygonatum Mill. belongs to the Liliaceae family, which is widely
distributed all over the world. Modern studies have found that Polygonatum plants are very …

Anticancer potential of betulonic acid derivatives

A Lombrea, AD Scurtu, S Avram, IZ Pavel… - International Journal of …, 2021 - mdpi.com
Clinical trials have evidenced that several natural compounds, belonging to the
phytochemical classes of alkaloids, terpenes, phenols and flavonoids, are effective for the …

Enhancement of phytosterol and triterpenoid production in plant hairy root cultures—simultaneous stimulation or competition?

A Rogowska, A Szakiel - Plants, 2021 - mdpi.com
Plant in vitro cultures, including hairy roots, can be applied for controlled production of
valuable natural products, such as triterpenoids and sterols. These compounds originate …