Chromatin compacts genomic DNA in eukaryotes. The primary chromatin unit is the
nucleosome core particle, composed of four pairs of the core histones, H2A, H2B, H3, and …

In eukaryotes, genomic DNA is compacted in chromatin, which generally suppresses
transcription, replication, repair, and recombination. The fundamental unit of chromatin is the …

Eukaryotes have a multitude of diverse mechanisms for organising and using their
genomes, but the histones that make up chromatin are highly conserved. Unusually …

The histone H2A variant H2A. W occupies transposons and thus prevents access to them in
Arabidopsis thaliana. H2A. W is deposited by the chromatin remodeler DDM1, which also …

Abstract Introduction Alzheimer apolipoprotein E (APOE) ɛ4/ɛ4 carriers have earlier
disease onset and more protein aggregates than patients with other APOE genotypes …

The histone H3 variant CENP-A is a crucial epigenetic marker for centromere specification.
CENP-A forms a characteristic nucleosome and dictates the higher-order configuration of …

Nucleosome breathing potentially increases the DNA exposure, which in turn recruits DNA-
binding protein and regulates gene transcription. Numerous studies have shown the critical …

Histone variants fine-tune transcription, replication, DNA damage repair, and faithful
chromosome segregation. Whether and how nucleosome variants encode unique …

Meters of DNA wrap around histone proteins to form nucleosomes and fit inside the micron-
diameter nucleus. For the genetic information encoded in the DNA to become available for …

Giardia lamblia is a pathogenic unicellular eukaryotic parasite that causes giardiasis. Its
genome encodes the canonical histones H2A, H2B, H3, and H4, which share low amino …