The nucleus accumbens is a major input structure of the basal ganglia and integrates
information from cortical and limbic structures to mediate goal-directed behaviors. Chronic …

Addiction is caused, in part, by powerful and long-lasting memories of the drug experience.
Relapse caused by exposure to cues associated with the drug experience is a major clinical …

Endocannabinoids (eCBs) are a family of lipid molecules that act as key regulators of
synaptic transmission and plasticity. They are synthetized “on demand” following …

Sleep is a vital function of the nervous system that contributes to brain and bodily
homeostasis, energy levels, cognitive ability, and other key functions of a variety of …

Endocannabinoids (eCBs) are key activity-dependent signals regulating synaptic
transmission throughout the central nervous system. Accordingly, eCBs are involved in …

The past two decades have witnessed a dramatic accumulation of evidence indicating that
the excitatory amino acid glutamate plays an important role in drug addiction and …

The corollaries of the obesity epidemic that plagues developed societies are malnutrition
and resulting biochemical imbalances. Low levels of essential n-3 polyunsaturated fatty …

Long-lasting changes of brain function in response to experience rely on diverse forms of
activity-dependent synaptic plasticity. Chief among them are long-term potentiation and long …

Marijuana has been used for thousands of years as a treatment for medical conditions.
However, untoward side effects limit its medical value. Here, we show that synaptic and …

Drug addiction is a chronic relapsing disorder that produces a dramatic global health burden
worldwide. Not effective treatment of drug addiction is currently available probably due to the …