The phosphatidylinositol 3 kinase (PI3K)/AKT pathway is genetically targeted in more
pathway components and in more tumor types than any other growth factor signaling …

The phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway regulates multiple cellular
processes. An overactivation of the pathway is frequently present in human malignancies …

Mutations that decrease or increase the activity of the tyrosine phosphatase, SHP2 (encoded
by PTPN11), promotes developmental disorders and several malignancies by varying …

Solid tumours are highly refractory to immune checkpoint blockade (ICB) therapies due to
the functional impairment of effector T cells and their inefficient trafficking to tumours. T-cell …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible
RNA virus that is the causative agent of the Coronavirus disease 2019 (COVID-19) …

Phospholipase D is a ubiquitous class of enzymes that generates phosphatidic acid as an
intracellular signaling species. The phospholipase D superfamily plays a central role in a …

Akt/PKB, a serine/threonine kinase member of the AGC family of proteins, is involved in the
regulation of a plethora of cellular processes triggered by a wide diversity of extracellular …

Tyrosine kinases belong to a family of enzymes that mediate the movement of the phosphate
group to tyrosine residues of target protein, thus transmitting signals from the cell surface to …

AKT/PKB serine threonine kinase, a critical signaling molecule promoting cell growth and
survival pathways, is frequently dysregulated in many cancers. Although …

Akt is a critical protein kinase that drives cancer proliferation, modulates metabolism, and is
activated by C-terminal phosphorylation. The current structural model for Akt activation by C …