A guide to the composition and functions of the extracellular matrix
Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that
provides structural support for the cells and tissues. Accumulated knowledge clearly …
provides structural support for the cells and tissues. Accumulated knowledge clearly …
3D extracellular matrix mimics: fundamental concepts and role of materials chemistry to influence stem cell fate
Synthetic 3D extracellular matrices (ECMs) find application in cell studies, regenerative
medicine, and drug discovery. While cells cultured in a monolayer may exhibit unnatural …
medicine, and drug discovery. While cells cultured in a monolayer may exhibit unnatural …
Proteoglycan chemical diversity drives multifunctional cell regulation and therapeutics
The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …
Regenerative scar-free skin wound healing
Scar formation is a common consequence of skin injuries that lead to a wide range of
adverse effects including physical deformities and psychological disorders. Studies …
adverse effects including physical deformities and psychological disorders. Studies …
Matrix modeling and remodeling: a biological interplay regulating tissue homeostasis and diseases
The overall structure and architecture of the extracellular matrix undergo dramatic alterations
in composition, form, and functionality over time. The stochasticity begins during …
in composition, form, and functionality over time. The stochasticity begins during …
Extracellular matrix: the driving force of mammalian diseases
RV Iozzo, MA Gubbiotti - Matrix Biology, 2018 - Elsevier
Like the major theme of a Mozart concerto, the immense and pervasive extracellular matrix
drives each movement and ultimately closes the symphony, embracing a unique role as the …
drives each movement and ultimately closes the symphony, embracing a unique role as the …
Proteoglycans remodeling in cancer: Underlying molecular mechanisms
AD Theocharis, NK Karamanos - Matrix Biology, 2019 - Elsevier
Extracellular matrix is a highly dynamic macromolecular network. Proteoglycans are major
components of extracellular matrix playing key roles in its structural organization and cell …
components of extracellular matrix playing key roles in its structural organization and cell …
The glycosaminoglycan interactome 2.0
SD Vallet, C Berthollier… - American Journal of …, 2022 - journals.physiology.org
Glycosaminoglycans (GAGs) are complex linear polysaccharides, which are covalently
attached to core proteins (except for hyaluronan) to form proteoglycans. They play key roles …
attached to core proteins (except for hyaluronan) to form proteoglycans. They play key roles …
Decorin and biglycan are necessary for maintaining collagen fibril structure, fiber realignment, and mechanical properties of mature tendons
KA Robinson, M Sun, CE Barnum, SN Weiss, J Huegel… - Matrix Biology, 2017 - Elsevier
The small leucine-rich proteoglycans (SLRPs), decorin and biglycan, are key regulators of
collagen fibril and matrix assembly. The goal of this work was to elucidate the roles of …
collagen fibril and matrix assembly. The goal of this work was to elucidate the roles of …
The role of decorin and biglycan signaling in tumorigenesis
V Diehl, LS Huber, J Trebicka, M Wygrecka… - Frontiers in …, 2021 - frontiersin.org
The complex and adaptive nature of malignant neoplasm constitute a major challenge for
the development of effective anti-oncogenic therapies. Emerging evidence has uncovered …
the development of effective anti-oncogenic therapies. Emerging evidence has uncovered …