In patients with uninjured lungs, increasing evidence indicates that tidal volume (VT)
reduction improves outcomes in the intensive care unit (ICU) and in the operating room …

This dissertation has addressed the broad hypothesis as to whether building mathematical
models is useful as a tool for translating physiological knowledge into clinical practice. In …

Management of mechanical ventilation in intensive care patients is complicated by
conflicting clinical goals. Decision support systems (DSS) may support clinicians in finding …

Mechanical ventilation is an effective treatment in the ICU but can have significant adverse
effects. Approaches from adult research have been adopted in pediatric critical care despite …

Mathematical models of the acid–base chemistry of blood based upon mass action and
mass balance equations have become popular as diagnostic tools in intensive care. The …

Background Choosing the correct ventilator settings for the treatment of patients with
respiratory tract disease is quite an important issue. Since the task of specifying the …

PURPOSE: The aim of the study was to prospectively evaluate a decision support system for
its ability to provide appropriate suggestions of inspired oxygen fraction in intensive care …

Ventilatory support, while life saving, can also cause or aggravate lung injury through
several mechanisms which are encompassed within ventilator-associated lung injury (VALI) …

Introduction Hypoxemia and high fractions of inspired oxygen (FiO 2) are concerns in
critically ill patients. An automated FiO 2 controller based on continuous oxygen saturation …

PURPOSE: The purpose of this study was to evaluate Danish clinicians' opinions toward
ventilator settings using standardized model-simulated patients. The models ensured that all …