A 'fourth wave'of high mortality involving methamphetamine and cocaine use has been
gathering force in the USA. Availability and use of illicit fentanyls are still the major drivers of …

Importance Mortality among people with opioid dependence is higher than that of the
general population. Opioid agonist treatment (OAT) is an effective treatment for opioid …

Importance The coronavirus disease 2019 (COVID-19) pandemic, associated mitigation
measures, and social and economic impacts may affect mental health, suicidal behavior …

Background Adversity experienced during childhood manifests deleteriously across the
lifespan. This study provides updated frequency estimates of ACEs using the most …

Opioid use disorder (OUD) is a chronic relapsing disorder that, whilst initially driven by
activation of brain reward neurocircuits, increasingly engages anti-reward neurocircuits that …

Importance US life expectancy has not kept pace with that of other wealthy countries and is
now decreasing. Objective To examine vital statistics and review the history of changes in …

The US mortality rate has gone up three years in a row from 2014 to 2017 (Xu, Murphy,
Kochanek, & Arias, 2016; Murphy, Xu, Kochanek, & Arias, 2018; Kochanek, Murphy, Xu, & …

Stigma as a fundamental hindrance to the United States opioid overdose crisis response |
PLOS Medicine Skip to main content Advertisement PLOS Medicine Browse Current Issue …

Importance More than 42 000 Americans died of opioid overdoses in 2016, and the fatalities
continue to increase. This review analyzes the factors that triggered the opioid crisis and its …

Objectives. To determine the magnitude of increases in monthly drug-related overdose
mortality during the COVID-19 pandemic in the United States. Methods. We leveraged …