The assembly of ribosomal subunits is a highly orchestrated process that involves a huge
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …

In the past 25 years, genetic and biochemical analyses of ribosome assembly in yeast have
identified most of the factors that participate in this complex pathway and have generated …

Ribosomes, which synthesize the proteins of a cell, comprise ribosomal RNA and ribosomal
proteins, which coassemble hierarchically during a process termed ribosome biogenesis …

Ribosomal RNAs are the most abundant and universal noncoding RNAs in living organisms.
In eukaryotes, three of the four ribosomal RNAs forming the 40S and 60S subunits are borne …

Ribosomes are highly conserved ribonucleoprotein nanomachines that translate information
in the genome to create the proteome in all cells. In yeast these complex particles contain …

Fibrillar centers (FCs) and dense fibrillar components (DFCs) are essential morphologically
distinct sub-regions of mammalian cell nucleoli for rDNA transcription and pre-rRNA …

The essential cellular process of ribosome biogenesis is at the nexus of various signalling
pathways that coordinate protein synthesis with cellular growth and proliferation. The fact …

Covalent attachment of small ubiquitin-like modifier (SUMO) to proteins is highly dynamic,
and both SUMO–protein conjugation and cleavage can be regulated. Protein desumoylation …

We have developed pLink, software for data analysis of cross-linked proteins coupled with
mass-spectrometry analysis. pLink reliably estimates false discovery rate in cross-link …

The biosynthesis of ribosomes is a complex process that requires the coordinated action of
many factors and a huge energy investment from the cell. Ribosomes are essential for …