The gut virome: A new microbiome component in health and disease

Z Cao, N Sugimura, E Burgermeister, MP Ebert… - …, 2022 - thelancet.com
The human gastrointestinal tract harbours an abundance of viruses, collectively known as
the gut virome. The gut virome is highly heterogeneous across populations and is linked to …

Phage therapy: going temperate?

R Monteiro, DP Pires, AR Costa, J Azeredo - Trends in microbiology, 2019 - cell.com
Strictly lytic phages have been consensually preferred for phage therapy purposes. In
contrast, temperate phages have been avoided due to an inherent capacity to mediate …

[HTML][HTML] New insights into intestinal phages

R Sausset, MA Petit, V Gaboriau-Routhiau… - Mucosal …, 2020 - Elsevier
The intestinal microbiota plays important roles in human health. This last decade, the viral
fraction of the intestinal microbiota, composed essentially of phages that infect bacteria …

Phage Paride can kill dormant, antibiotic-tolerant cells of Pseudomonas aeruginosa by direct lytic replication

E Maffei, AK Woischnig, MR Burkolter, Y Heyer… - Nature …, 2024 - nature.com
Bacteriophages are ubiquitous viral predators that have primarily been studied using fast-
growing laboratory cultures of their bacterial hosts. However, microbial life in nature is …

Bacteriophage-mediated spread of bacterial virulence genes

JR Penadés, J Chen, N Quiles-Puchalt… - Current opinion in …, 2015 - Elsevier
Highlights•Phage-mediated transduction drives bacterial evolution.•pac-phages can
package any bacterial DNA.•Both pac and cos phages can transfer mobile genetic …

Black box of phage–bacterium interactions: Exploring alternative phage infection strategies

S Mäntynen, E Laanto, HM Oksanen… - Open …, 2021 - royalsocietypublishing.org
The canonical lytic–lysogenic binary has been challenged in recent years, as more
evidence has emerged on alternative bacteriophage infection strategies. These infection …

The human gut phage community and its implications for health and disease

P Manrique, M Dills, MJ Young - Viruses, 2017 - mdpi.com
In this review, we assess our current understanding of the role of bacteriophages infecting
the human gut bacterial community in health and disease. In general, bacteriophages …

The life cycle transitions of temperate phages: regulating factors and potential ecological implications

M Zhang, T Zhang, M Yu, YL Chen, M Jin - Viruses, 2022 - mdpi.com
Phages are viruses that infect bacteria. They affect various microbe-mediated processes that
drive biogeochemical cycling on a global scale. Their influence depends on whether the …

Applications of bacteriophages versus phage enzymes to combat and cure bacterial infections: an ambitious and also a realistic application?

B Maciejewska, T Olszak, Z Drulis-Kawa - Applied microbiology and …, 2018 - Springer
Bacteriophages (phages) are viruses that infect bacteria. The “predator–prey” interactions
are recognized as a potentially effective way to treat infections. Phages, as well as phage …

Gnotobiotic mouse model of phage–bacterial host dynamics in the human gut

A Reyes, M Wu, NP McNulty… - Proceedings of the …, 2013 - National Acad Sciences
Bacterial viruses (phages) are the most abundant biological group on Earth and are more
genetically diverse than their bacterial prey/hosts. To characterize their role as agents …