Simple Summary The Hedgehog/GLI (Hh/GLI) pathway plays a major role during
development and it is commonly dysregulated in many diseases, including cancer. This …

The hedgehog (HH) signaling pathway regulates normal cell growth and differentiation. As a
consequence of improper control, aberrant HH signaling results in tumorigenesis and …

Triple-negative breast cancer (TNBC) is the most complex, aggressive and fatal subtype of
breast cancer. Owing to the lack of targeted therapy and heterogenic nature of TNBC …

The characteristics of an organism are determined by the genes expressed within it. A
method was developed, called serial analysis of gene expression (SAGE), that allows the …

Gli zinc-finger proteins are transcription factors involved in the intracellular signal
transduction controlled by the Hedgehog family of secreted molecules. They are frequently …

The basal cell nevus syndrome (BCNS) is characterized by developmental abnormalities
and by the postnatal occurrence of cancers, especially basal cell carcinomas (BCCs), the …

Proper regulation of chondrocyte differentiation is necessary for the morphogenesis of
skeletal elements, yet little is known about the molecular regulation of this process. A …

The neuron-restrictive silencer factor (NRSF) binds a DNA sequence element, called the
neuron-restrictive silencer element (NRSE), that represses neuronal gene transcription in …

Granule cells (GCs) are the most numerous cell type in the cerebellum and indeed, in the
brain: at least 99% of all cerebellar neurons are granule cells. In this review article, we first …

A sequence within the transcription control region of the adeno-associated virus P5
promoter has been shown to mediate transcriptional activation by the adenovirus EIA …