Heterogeneity in NECTIN4 Expression Across Molecular Subtypes of Urothelial Cancer Mediates Sensitivity to Enfortumab Vedotin
Purpose: Enfortumab vedotin (EV) is an antibody–drug conjugate (ADC) targeting NECTIN4
(encoded by the PVRL4/NECTIN4 gene) approved for treatment-refractory metastatic …
(encoded by the PVRL4/NECTIN4 gene) approved for treatment-refractory metastatic …
Are we ready to implement molecular subtyping of bladder cancer in clinical practice? Part 1: general issues and marker expression
F Sanguedolce, M Zanelli, A Palicelli, S Ascani… - International Journal of …, 2022 - mdpi.com
Bladder cancer (BC) is a heterogeneous disease with highly variable clinical and
pathological features, and resulting in different outcomes. Such heterogeneity ensues from …
pathological features, and resulting in different outcomes. Such heterogeneity ensues from …
Are we ready to implement molecular subtyping of bladder cancer in clinical practice? Part 2: subtypes and divergent differentiation
F Sanguedolce, M Zanelli, A Palicelli, S Ascani… - International Journal of …, 2022 - mdpi.com
Following several attempts to achieve a molecular stratification of bladder cancer (BC) over
the last decade, a “consensus” classification has been recently developed to provide a …
the last decade, a “consensus” classification has been recently developed to provide a …
Glucose metabolism reprogramming in bladder cancer: hexokinase 2 (HK2) as prognostic biomarker and target for bladder cancer therapy
Simple Summary Urothelial bladder carcinoma entails significant health costs due to the
high recurrence rates and poor response to standard cisplatin-based treatment. The …
high recurrence rates and poor response to standard cisplatin-based treatment. The …
Bladder cancer cell‐intrinsic PD‐L1 signals promote mTOR and autophagy activation that can be inhibited to improve cytotoxic chemotherapy
Tumor cell‐intrinsic programmed death‐ligand 1 (PD‐L1) signals mediate
immunopathologic effects in breast, colon, and ovarian cancers and in melanomas, but …
immunopathologic effects in breast, colon, and ovarian cancers and in melanomas, but …
[HTML][HTML] Three-dimensional organoid culture reveals involvement of Wnt/β-catenin pathway in proliferation of bladder cancer cells
There has been increasing awareness of the importance of three-dimensional culture of
cancer cells. Tumor cells growing as multicellular spheroids in three-dimensional culture …
cancer cells. Tumor cells growing as multicellular spheroids in three-dimensional culture …
CD44s is a crucial ATG7 downstream regulator for stem-like property, invasion, and lung metastasis of human bladder cancer (BC) cells
J Zhu, G Huang, X Hua, Y Li, H Yan, X Che, Z Tian… - Oncogene, 2019 - nature.com
Over half a million US residents are suffering with bladder cancer (BC), which costs a total
$4 billion in treatment annually. Although recent studies report that autophagy-related gene …
$4 billion in treatment annually. Although recent studies report that autophagy-related gene …
Profiling and targeting of energy and redox metabolism in grade 2 bladder cancer cells with different invasiveness properties
V Pasquale, G Ducci, G Campioni, A Ventrici… - Cells, 2020 - mdpi.com
Bladder cancer is one of the most prevalent deadly diseases worldwide. Grade 2 tumors
represent a good window of therapeutic intervention, whose optimization requires high …
represent a good window of therapeutic intervention, whose optimization requires high …
Epithelial-to-mesenchymal transition enhances cancer cell sensitivity to cytotoxic effects of cold atmospheric plasmas in breast and bladder cancer systems
Simple Summary Cold atmospheric plasma (CAP) and plasma-activated medium (PAM) are
known to selectively kill cancer cells, however the efficacy of CAP in cancer cells following …
known to selectively kill cancer cells, however the efficacy of CAP in cancer cells following …
Transcription factor EB regulates phosphatidylinositol-3-phosphate levels that control lysosome positioning in the bladder cancer model
Lysosomes orchestrate degradation and recycling of exogenous and endogenous material
thus controlling cellular homeostasis. Little is known how this organelle changes during …
thus controlling cellular homeostasis. Little is known how this organelle changes during …