Amyotrophic lateral sclerosis (ALS) is a fatal, multigenic, multifactorial, and non-cell
autonomous neurodegenerative disease characterized by upper and lower motor neuron …

ABSTRACT Introduction: The sigma-1 receptor (S1R) is attracting much attention for disease-
modifying therapies in neurodegenerative diseases. It is a conserved protein, present in …

Transactive response DNA-binding protein of 43 kDa (TDP-43) functions as a
heterogeneous nuclear ribonucleoprotein and is the major pathological protein in …

Amyotrophic Lateral Sclerosis (ALS), is a fatal neurodegenerative disorder, with TDP-43
inclusions as a major pathological hallmark. Using a Drosophila model of TDP-43 …

Background Cytoplasmic inclusions of transactive response DNA binding protein of 43 kDa
(TDP-43) in neurons and astrocytes are a feature of some neurodegenerative diseases …

In order to dissect amyotrophic lateral sclerosis (ALS), a multigenic, multifactorial, and
progressive neurodegenerative disease with heterogeneous clinical presentations …

The development, maturation, and maintenance of the mammalian nervous system rely on
complex spatiotemporal patterns of gene expression. In neurons, this is achieved by the …

Amyotrophic lateral sclerosis (ALS) is a rare, devastating disease, causing movement
impairment, respiratory failure and ultimate death. A plethora of genetic, cellular and …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that
primarily affects motor neurons and causes muscle atrophy, paralysis, and death. While a …

Many lines of evidence have indicated the therapeutic potential of rescuing mitochondrial
integrity by targeting specific mitochondrial quality control pathways in neurodegenerative …