Neuroinflammation is a hallmark of many neurodegenerative diseases (NDs) and plays a
fundamental role in mediating the onset and progression of disease. Microglia, which …

Microglial cells are the resident macrophages in the central nervous system. These cells of
mesodermal/mesenchymal origin migrate into all regions of the central nervous system …

It is well accepted that CNS inflammation has a role in the progression of chronic
neurodegenerative disease, although the mechanisms through which this occurs are still …

There is growing evidence that obesity has deleterious effects on the brain and cognitive
function in the elderly population. However, the specific mechanisms through which aging …

This review aims to point out that chronic stress is able to accelerate the appearance of
Alzheimer's disease (AD), proposing the former as a risk factor for the latter. Firstly, in the …

There is increasing evidence for blood–brain barrier (BBB) alterations in Parkinson's
disease (PD), the second most common neurodegenerative disorder with rapidly rising …

Preconditioning is a phenomenon in which brief episodes of a sublethal insult induce robust
protection against subsequent lethal injuries. Preconditioning has been observed in multiple …

Increasing lines of evidence show that resveratrol, a polyphenol compound contained in
several dietary products, exhibits cytoprotective actions. Notably, resveratrol activates sirtuin …

There is increasing evidence that prothrombin and its active derivative thrombin are
expressed locally in the central nervous system. So far, little is known about the …

We have evaluated the potential neuroprotectant activity of minocycline in an animal model
of Parkinson's disease induced by intranigral injection of lipopolysaccharide. Minocycline …