Telomerase, the enzyme that replenishes telomeres, is essential for most eukaryotes to
maintain their generations. Telomere length homeostasis is achieved via a balance between …

Specific proteins present at telomeres ensure chromosome end stability, in large part
through unknown mechanisms. In this work, we address how the Saccharomyces cerevisiae …

Telomeres play important roles in safeguarding the genome. The specialized repressive
chromatin that assembles at telomeres and subtelomeric domains is key to this protective …

Telomeres and the shelterin complex cap and protect the ends of chromosomes. Telomeres
are flanked by the subtelomeric sequences that have also been implicated in telomere …

A subset of cancers rely on telomerase-independent mechanisms to maintain their
chromosome ends. The predominant “alternative lengthening of telomeres” pathway …

The conserved shelterin complex caps chromosome ends to protect telomeres and regulate
telomere replication. In fission yeast Schizosaccharomyces pombe, shelterin consists of …

Telomeres protect chromosome ends and are distinguished from DNA double-strand breaks
(DSBs) by means of a specialized chromatin composed of DNA repeats bound by a …

Background Telomeres are chromosome end structures important in the maintenance of
genome homeostasis. They are replenished by the action of telomerase and associated …

Shelterin is a six-protein complex that coats chromosome ends to ensure their proper
protection and maintenance. Similar to the human shelterin, fission yeast shelterin is …

Chromosome ends are protected from erosion and chromosomal fusions through telomeric
repeats and the telomere-binding protein complex shelterin. Imperfect repetitive sequences …