[HTML][HTML] The PI3K/Akt/mTOR pathway in lung cancer; oncogenic alterations, therapeutic opportunities, challenges, and a glance at the application of nanoparticles
MJ Sanaei, S Razi, A Pourbagheri-Sigaroodi… - Translational …, 2022 - Elsevier
Lung cancer is the leading cause of cancer-related mortality worldwide. Although the
PI3K/Akt/mTOR signaling pathway has recently been considered as one of the most altered …
PI3K/Akt/mTOR signaling pathway has recently been considered as one of the most altered …
Role of autophagy and apoptosis in non-small-cell lung cancer
Non-small-cell lung cancer (NSCLC) constitutes 85% of all lung cancers, and is the leading
cause of cancer-related death worldwide. The poor prognosis and resistance to both …
cause of cancer-related death worldwide. The poor prognosis and resistance to both …
Targeting PI3K/AKT/mTOR pathway in non small cell lung cancer
C Fumarola, MA Bonelli, PG Petronini… - Biochemical …, 2014 - Elsevier
Abstract While PI3K/AKT/mTOR pathway is altered in a variety of cancers including non
small cell lung cancer, abnormalities in this pathway are more common in squamous cell …
small cell lung cancer, abnormalities in this pathway are more common in squamous cell …
Mitochondria‐ros crosstalk in the control of cell death and aging
Reactive oxygen species (ROS) are highly reactive molecules, mainly generated inside
mitochondria that can oxidize DNA, proteins, and lipids. At physiological levels, ROS …
mitochondria that can oxidize DNA, proteins, and lipids. At physiological levels, ROS …
Autophagy in health and disease: From molecular mechanisms to therapeutic target
Macroautophagy/autophagy is an evolutionally conserved catabolic process in which
cytosolic contents, such as aggregated proteins, dysfunctional organelle, or invading …
cytosolic contents, such as aggregated proteins, dysfunctional organelle, or invading …
Autophagy regulation and its role in cancer
S Lorin, A Hamaï, M Mehrpour, P Codogno - Seminars in cancer biology, 2013 - Elsevier
The modulation of macroautophagy is now recognized as one of the hallmarks of cancer
cells. There is accumulating evidence that autophagy plays a role in the various stages of …
cells. There is accumulating evidence that autophagy plays a role in the various stages of …
[HTML][HTML] The phosphatidylinositol 3-kinase/Akt/mTOR signaling network as a therapeutic target in acute myelogenous leukemia patients
AM Martelli, C Evangelisti, F Chiarini, JA McCubrey - Oncotarget, 2010 - ncbi.nlm.nih.gov
Abstract The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin
(mTOR) signaling axis plays a central role in cell proliferation, growth, and survival under …
(mTOR) signaling axis plays a central role in cell proliferation, growth, and survival under …
[HTML][HTML] Emerging anti-aging strategies-scientific basis and efficacy
The prevalence of age-related diseases is in an upward trend due to increased life
expectancy in humans. Age-related conditions are among the leading causes of morbidity …
expectancy in humans. Age-related conditions are among the leading causes of morbidity …
The autophagic paradox in cancer therapy
WKK Wu, SB Coffelt, CH Cho, XJ Wang, CW Lee… - Oncogene, 2012 - nature.com
Autophagy, hallmarked by the formation of double-membrane bound organelles known as
autophagosomes, is a lysosome-dependent pathway for protein degradation. The role of …
autophagosomes, is a lysosome-dependent pathway for protein degradation. The role of …
New insights into Notch1 regulation of the PI3K–AKT–mTOR1 signaling axis: Targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia
EC Hales, JW Taub, LH Matherly - Cellular signalling, 2014 - Elsevier
T-cell acute lymphoblastic leukemia (T-ALL) is characterized as a high-risk stratified disease
associated with frequent relapse, chemotherapy resistance, and a poorer prognostic outlook …
associated with frequent relapse, chemotherapy resistance, and a poorer prognostic outlook …