Cisplatin is an effective chemotherapeutic agent for various solid tumours, but its use is
limited by adverse effects in normal tissues. In particular, cisplatin is nephrotoxic and can …

Oxidative stress (OS) has greatly interested the research community in understanding
damaging processes occurring in cells. OS is triggered by an imbalance between reactive …

Aims: Ischemia-reperfusion injury (IRI)-induced acute kidney injury (IRI-AKI) is characterized
by elevated levels of reactive oxygen species (ROS), mitochondrial dysfunction, and …

Mitochondria are essential for the activity, function and viability of eukaryotic cells and
mitochondrial dysfunction is involved in the pathogenesis of acute kidney injury (AKI) and …

Oxidative stress (OS), defined as redox imbalance in favor of oxidant burden, is one of the
most significant biological events in cancer progression. Cancer cells generally represent a …

Mitochondria are essential organelles in physiology and kidney diseases, because they
produce cellular energy required to perform their function. During mitochondrial metabolism …

Cisplatin is a widely used chemotherapeutic agent used to treat solid tumours, such as
ovarian, head and neck, and testicular germ cell. A known complication of cisplatin …

Acute kidney injury (AKI) has been widely recognized as an important risk factor for the
occurrence and development of chronic kidney disease (CKD). Even milder AKI has adverse …

The death of cardiomyocytes either through apoptosis or necroptosis is the pathological
feature of cardiac ischemia-reperfusion (I/R) injury. Phosphoglycerate mutase 5 (PGAM5), a …

Myocardial infarction (MI) is a leading cause of morbidity and mortality worldwide. As
mitochondrial dysfunction critically contributes to the pathogenesis of MI, intensive research …