Genomic DNA barcoding has emerged as a sensitive and flexible tool to measure the fates
of clonal subpopulations within a heterogeneous cancer cell population. Coupling cellular …

Phenotypic plasticity was recently incorporated as a hallmark of cancer. This plasticity can
manifest along many interconnected axes, such as stemness and differentiation, drug …

Cancer is a significant global health issue, with treatment challenges arising from intratumor
heterogeneity. This heterogeneity stems mainly from somatic evolution, causing genetic …

Chemotherapy resistance in cancer remains a barrier to curative therapy in advanced
disease. Dosing of chemotherapy is often chosen based on the maximum tolerated dosing …

Several studies in the last few years have determined that, in contrast to the prevailing
dogma that drug resistance is simply due to Darwinian evolution—the selection of mutant …

In this article, we review the role of mathematical modelling to elucidate the impact of tumor-
associated macrophages (TAMs) in tumor progression and therapy design. We first outline …

Purpose Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide.
The occurrence and development of HCC are closely related to epigenetic modifications …

Recent preclinical and clinical studies have suggested that evolution-based cancer
therapies exploiting intratumor competition can significantly delay resistance. Various …

With the exponential growth of the volume of scientific literature, it is particularly important to
grasp the research frontier. Predicting emerging research topics will help research …

Introduction Breast cancer is the second most diagnosed cancer, as well as the primary
cause of cancer death in women worldwide. Of the different breast cancer subtypes, triple …