Anti-cancer peptides: classification, mechanism of action, reconstruction and modification

M Xie, D Liu, Y Yang - Open biology, 2020 - royalsocietypublishing.org
Anti-cancer peptides (ACPs) are a series of short peptides composed of 10–60 amino acids
that can inhibit tumour cell proliferation or migration, or suppress the formation of tumour …

Polymerization of ethylene oxide, propylene oxide, and other alkylene oxides: synthesis, novel polymer architectures, and bioconjugation

J Herzberger, K Niederer, H Pohlit, J Seiwert… - Chemical …, 2016 - ACS Publications
The review summarizes current trends and developments in the polymerization of alkylene
oxides in the last two decades since 1995, with a particular focus on the most important …

[HTML][HTML] Biomimetic hydrogels designed for cartilage tissue engineering

KD Ngadimin, A Stokes, P Gentile, AM Ferreira - Biomaterials science, 2021 - pubs.rsc.org
Cartilage regeneration and repair remain a clinical challenge due to the limited capability of
cartilage to self-regenerate. Worldwide, the costs associated with cartilage regeneration per …

Targeting of antithrombin in hemophilia A or B with RNAi therapy

KJ Pasi, S Rangarajan, P Georgiev… - … England Journal of …, 2017 - Mass Medical Soc
Background Current hemophilia treatment involves frequent intravenous infusions of clotting
factors, which is associated with variable hemostatic protection, a high treatment burden …

Atom transfer radical polymerization (ATRP): current status and future perspectives

K Matyjaszewski - Macromolecules, 2012 - ACS Publications
Current status and future perspectives in atom transfer radical polymerization (ATRP) are
presented. Special emphasis is placed on mechanistic understanding of ATRP, recent …

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates

BQ Shen, K Xu, L Liu, H Raab, S Bhakta… - Nature …, 2012 - nature.com
The reactive thiol in cysteine is used for coupling maleimide linkers in the generation of
antibody conjugates. To assess the impact of the conjugation site, we engineered cysteines …

Bioorthogonal chemistry: fishing for selectivity in a sea of functionality

EM Sletten, CR Bertozzi - Angewandte Chemie International …, 2009 - Wiley Online Library
The study of biomolecules in their native environments is a challenging task because of the
vast complexity of cellular systems. Technologies developed in the last few years for the …

Enzyme-responsive nanoparticles for drug release and diagnostics

R De La Rica, D Aili, MM Stevens - Advanced drug delivery reviews, 2012 - Elsevier
Enzymes are key components of the bionanotechnology toolbox that possess exceptional
biorecognition capabilities and outstanding catalytic properties. When combined with the …

State of the art in PEGylation: the great versatility achieved after forty years of research

G Pasut, FM Veronese - Journal of controlled release, 2012 - Elsevier
In the recent years, protein PEGylation has become an established and highly refined
technology by moving forward from initial simple random coupling approaches based on …

Sequence-and stereo-defined macromolecules: properties and emerging functionalities

R Szweda - Progress in Polymer Science, 2023 - Elsevier
Natural macromolecules, such as proteins and nucleic acids, display various complex
functionalities in biological systems. These functionalities depend on the macromolecular …