ATPases associated with diverse cellular activities (AAA+ proteins) are a superfamily of
proteins found throughout all domains of life. The hallmark of this family is a conserved …

The INO80 family of chromatin remodellers are multisubunit complexes that perform a
variety of tasks on nucleosomes. Family members are built around a heterohexamer of RuvB …

In the eukaryotic nucleus, DNA is packaged in the form of nucleosomes, each of which
comprises about 147 base pairs of DNA wrapped around a histone protein octamer. The …

Access to DNA within nucleosomes is required for a variety of processes in cells including
transcription, replication and repair. Consequently, cells encode multiple systems that …

The nucleosomal landscape of chromatin depends on the concerted action of chromatin
remodelers. The INO80 remodeler specifically places nucleosomes at the boundary of gene …

INTRODUCTION Canonical nucleosomes contain two copies of each of four histone
proteins: H2A, H2B, H3, and H4. However, variants of these histones can be inserted by …

We present a cross-linking/mass spectrometry workflow for performing proteome-wide cross-
linking analyses within 1 week. The workflow is based on the commercially available mass …

Mammalian TIP60 is a multi-functional enzyme with histone acetylation and histone dimer
exchange activities. It plays roles in diverse cellular processes including transcription, DNA …

Epigenetic dysregulation is reported in multiple cancers including Ewing sarcoma (EwS).
However, the epigenetic networks underlying the maintenance of oncogenic signaling and …

Nuclear actin (N-actin) and actin-related proteins (Arps) are critical components of several
chromatin modulating complexes, including the chromatin remodeler INO80, but their …