History and progress of hypotheses and clinical trials for Alzheimer's disease

PP Liu, Y Xie, XY Meng, JS Kang - Signal transduction and targeted …, 2019 - nature.com
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive
memory loss along with neuropsychiatric symptoms and a decline in activities of daily life. Its …

Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics

AA Belaidi, AI Bush - Journal of neurochemistry, 2016 - Wiley Online Library
Brain iron homeostasis is increasingly recognized as a potential target for the development
of drug therapies for aging‐related disorders. Dysregulation of iron metabolism associated …

Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC

B Do Van, F Gouel, A Jonneaux, K Timmerman… - Neurobiology of …, 2016 - Elsevier
Parkinson's disease (PD) is a complex illness characterized by progressive dopaminergic
neuronal loss. Several mechanisms associated with the iron-induced death of dopaminergic …

Iron in neurodegeneration–cause or consequence?

A Ndayisaba, C Kaindlstorfer… - Frontiers in neuroscience, 2019 - frontiersin.org
Iron dyshomeostasis can cause neuronal damage to iron-sensitive brain regions.
Neurodegeneration with brain iron accumulation reflects a group of disorders caused by iron …

[HTML][HTML] Iron mediated toxicity and programmed cell death: A review and a re-examination of existing paradigms

R Eid, NTT Arab, MT Greenwood - … et Biophysica Acta (BBA)-Molecular Cell …, 2017 - Elsevier
Iron is an essential micronutrient that is problematic for biological systems since it is toxic as
it generates free radicals by interconverting between ferrous (Fe 2+) and ferric (Fe 3+) forms …

Gut microbiome–micronutrient interaction: The key to controlling the bioavailability of minerals and vitamins?

M Barone, F D'amico, P Brigidi, S Turroni - Biofactors, 2022 - Wiley Online Library
Micronutrients, namely, vitamins and minerals, are necessary for the proper functioning of
the human body, and their deficiencies can have dramatic short‐and long‐term health …

Iron and dopamine: a toxic couple

DJ Hare, KL Double - Brain, 2016 - academic.oup.com
Iron accumulation is a cardinal feature of degenerating regions in the Parkinson's disease
brain. As a potent pro-oxidant, redox-active iron may be a key player in upstream …

Gut–brain axis as a pathological and therapeutic target for neurodegenerative disorders

ARL Toledo, GR Monroy, FE Salazar, JY Lee… - International journal of …, 2022 - mdpi.com
Human lifestyle and dietary behaviors contribute to disease onset and progression.
Neurodegenerative diseases (NDDs), considered multifactorial disorders, have been …

Changes in ferrous iron and glutathione promote ferroptosis and frailty in aging Caenorhabditis elegans

NL Jenkins, SA James, A Salim, F Sumardy, TP Speed… - Elife, 2020 - elifesciences.org
All eukaryotes require iron. Replication, detoxification, and a cancer-protective form of
regulated cell death termed ferroptosis, all depend on iron metabolism. Ferrous iron …

[HTML][HTML] Excess iron intake as a factor in growth, infections, and development of infants and young children

B Lönnerdal - The American journal of clinical nutrition, 2017 - Elsevier
The provision of iron via supplementation or the fortification of foods has been shown to be
effective in preventing and treating iron deficiency and iron deficiency anemia in infants and …