Tightly orchestrated programmed cell death (PCD) signalling events occur during normal
neuronal development in a spatially and temporally restricted manner to establish the neural …

Ferroptosis is an iron-and lipid peroxidation-dependent cell death modality and emerging
evidence indicates that ferroptosis has great explanatory potential for neuronal loss and …

Amyotrophic lateral sclerosis (ALS) is a rapidly debilitating fatal neurodegenerative disorder,
causing muscle atrophy and weakness, which leads to paralysis and eventual death. ALS …

Copper, manganese, and iron are vital elements required for the appropriate development
and the general preservation of good health. Additionally, these essential metals play key …

Significance: The lack of disease-modifying treatments for Alzheimer's disease (AD) that
substantially alter the course of the disease highlights the need for new biological models of …

The pathophysiology of ALS involves many signs of a disruption in copper homeostasis, with
both excess free levels and functional deficiency likely occurring simultaneously. This is …

Globally, millions of individuals are impacted by neurodegenerative disorders including
Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD) …

Free radicals are unstable chemical reactive species produced during Redox
dyshomeostasis (RDH) inside living cells and are implicated in the pathogenesis of various …

Cuproptosis, a newly characterized form of regulated cell death driven by copper
accumulation, has emerged as a significant mechanism underlying various non-cancerous …

The recently discovered neurological disorder NEDAMSS is caused by heterozygous
truncations in the transcriptional regulator IRF2BPL. Here, we reprogram patient skin …