Overview of the antioxidant and anti-inflammatory activities of selected plant compounds and their metal ions complexes

P Mucha, A Skoczyńska, M Małecka, P Hikisz… - Molecules, 2021 - mdpi.com
Numerous plant compounds and their metal-ion complexes exert antioxidative, anti-
inflammatory, anticancer, and other beneficial effects. This review highlights the different …

Biochemical pathways of copper complexes: Progress over the past 5 years

S Zehra, S Tabassum, F Arjmand - Drug Discovery Today, 2021 - Elsevier
Highlights•Overview of copper complexes as potent anticancer chemotherapeutic
agents.•Copper complexes are endogenously biocompatible and exhibit reduced side …

Synthesis of palladium (II) complexes via Michael addition: antiproliferative effects through ROS-mediated mitochondrial apoptosis and docking with SARS-CoV-2

J Haribabu, S Srividya, D Mahendiran… - Inorganic …, 2020 - ACS Publications
Metal complexes have numerous applications in the current era, particularly in the field of
pharmaceutical chemistry and catalysis. A novel synthetic approach for the same is always a …

Cu-related agents for cancer therapies

C Wang, X Yang, C Dong, K Chai, J Ruan… - Coordination Chemistry …, 2023 - Elsevier
As an indispensable micronutrient, copper (Cu) plays an important role in promoting
metabolism and maintaining various basic biological functions. Copper homeostasis in the …

Michael addition-driven synthesis of cytotoxic palladium (ii) complexes from chromone thiosemicarbazones: investigation of anticancer activity through in vitro and in …

J Haribabu, N Balakrishnan, S Swaminathan… - New Journal of …, 2023 - pubs.rsc.org
Three Pd (II) complexes (1–3) containing tridentate chromone-based thiosemicarbazones
(SVSHL1–3) have been investigated as potential anticancer agents. The complexes of the …

Discovery of thirteen cobalt (II) and copper (II) salicylaldehyde Schiff base complexes that induce apoptosis and autophagy in human lung adenocarcinoma A549/DDP …

YT Chen, SN Zhang, ZF Wang, QM Wei… - Dalton Transactions, 2022 - pubs.rsc.org
In this study, 13 transition metal complexes, namely,[Cu (L1H)(H2O) 2]·(H2O)· NO3 (1),[Cu
(LnH2) 2]·(NO3)·(H2O) 2 (2, n= 2; 3, n= 3; 4, n= 4; 5, n= 5),[Co (LnH) 2] 2·(H2O) 0.5 (6, n= 2; …

Effect of N-benzyl group in indole scaffold of thiosemicarbazones on the biological activity of their Pd (II) complexes: DFT, biomolecular interactions, in silico docking …

N Balakrishnan, J Haribabu, RE Malekshah… - Inorganica Chimica …, 2022 - Elsevier
A series of N-benzyl substituted indole-based thiosemicarbazone (TSC) ligands (L4-L6) and
palladium (II) TSC complexes,[Pd (L) 2](1–6)(L= monoanionic bidentate un/N-substituted …

Influence of Indole-N Substitution of Thiosemicarbazones in Cationic Ru(II)(η6-Benzene) Complexes on Their Anticancer Activity

N Balakrishnan, J Haribabu, M Dharmasivam… - …, 2023 - ACS Publications
Indole thiosemicarbazones (TSCs) and their complexes are known to possess various
biological activities. The variation in anticancer activity with different indole-N substituents of …

Chromone, a privileged scaffold in drug discovery: Developments in the synthesis and bioactivity

AT Benny, SD Arikkatt, CG Vazhappilly… - Mini Reviews in …, 2022 - ingentaconnect.com
Chromones are the class of secondary metabolites that broadly occur in the plant kingdom
in a noticeable quantity. This rigid bicyclic system has been categorized “as privileged …

N-substitution in isatin thiosemicarbazones decides nuclearity of Cu (II) complexes–Spectroscopic, molecular docking and cytotoxic studies

J Haribabu, OI Alajrawy, K Jeyalakshmi… - … Acta Part A: Molecular …, 2021 - Elsevier
Abstract The mono-(1) and bi-nuclear (2) copper (II) complexes containing N-substituted
isatin thiosemicarbazone (s) were synthesized, and characterized by analytical and …