Background Assessments of age-specific mortality and life expectancy have been done by
the UN Population Division, Department of Economics and Social Affairs (UNPOP), the …

Patients with heart failure often develop cardiac arrhythmias. The mechanisms and
interrelations linking heart failure and arrhythmias are not fully understood. Historically …

Predicting the electrical behavior of the heart, from the cellular scale to the tissue level, relies
on the numerical approximation of coupled nonlinear dynamical systems. These systems …

Cardiac in silico clinical trials can virtually assess the safety and efficacy of therapies using
human-based modelling and simulation. These technologies can provide mechanistic …

Background Pseudonormal T waves may be detected on stress electrocardiograms (ECGs)
in hypertrophic cardiomyopathy (HCM). Either myocardial ischaemia or purely exercise …

The best pharmacological treatment for each atrial fibrillation (AF) patient is unclear. We aim
to exploit AF simulations in 800 virtual atria to identify key patient characteristics that guide …

Atrial fibrillation (AF) inducibility, sustainability and response to pharmacological treatment of
individual patients are expected to be determined by their ionic current properties, especially …

Cardiac Purkinje networks are a fundamental part of the conduction system and are known
to initiate a variety of cardiac arrhythmias. However, patient-specific modeling of Purkinje …

Personalized cardiac electrophysiology simulations have demonstrated great potential to
study cardiac arrhythmias and help in therapy planning of radio-frequency ablation. Its …

Ectopic beats are known to be involved in the initiation of a variety of cardiac arrhythmias.
Although their location may vary, ectopic excitations have been found to originate from …