The role of the immune system in shaping cancer development and patient prognosis has
recently become an area of intense focus in industry and academia. Harnessing the …

Background Breast cancer is one of the most frequently diagnosed cancers among women
worldwide, characterized by diverse biological heterogeneity. It is well known that complex …

Drug resistance to approved systemic therapies in estrogen receptor–positive (ER+) breast
cancer remains common. We hypothesized that factors present in the human tumor …

A new approach is presented to predict breast cancer recurrence through gene expression
profiles using hidden Markov models (HMM). In this regard, 322 genes were selected from …

Background Skeletal muscle satellite (stem) cells are quiescent in adult mice and can
undergo multiple rounds of proliferation and self-renewal following muscle injury. Several …

Metastatic breast cancer is characterized by aggressive spreading to distant organs. Despite
huge multilevel research, there are still several important challenges that have to be clarified …

The Cancer Genome Atlas project has generated multi-dimensional and highly integrated
genomic data from a large number of patient samples with detailed clinical records across …

Despite the success of approved systemic therapies for estrogen receptor α (ER)-positive
breast cancer, drug resistance remains common. We hypothesized that secreted factors from …

The onset and progression of a disease are often associated with changes in the expression
of groups of genes from a particular molecular pathway. Gene set enrichment analysis has …

Objective To characterize leucine-rich repeat containing G protein-coupled receptor 5–
positive (LGR5+) cells from the endometrium of women with endometriosis. Design …