Background and aims Individuals with a substance use disorder (SUD) have high rates of
hospital service utilization including emergency department (ED) presentations and hospital …

Importance Previous studies on the comparative effectiveness between buprenorphine and
methadone provided limited evidence on differences in treatment effects across key …

Introduction The COVID-19 pandemic was preceded by an ongoing overdose crisis and
linked to escalating drug overdose deaths in British Columbia (BC). At the outset of these …

Background Opioid overdoses are a leading cause of injury death in the United States.
Providing people who inject drugs (PWID) with naloxone is essential to preventing deaths …

Abstract Aims In March 2020, British Columbia issued Risk Mitigation Guidance (RMG) to
support prescribing of pharmaceutical alternatives to illicit drugs, in order to reduce risk for …

Introduction The ongoing opioid overdose crisis, which has killed over 30,000 people in
Canada since 2016, is driven by the volatility of an unregulated opioid drug supply …

Background Medication for opioid use disorder (MOUD) is associated with substantial
reductions in the risk of mortality, and American and Canadian guidelines recommend it as …

North America has been home to an unprecedented crisis of drug overdose deaths, driven
largely by drug users' exposure to highly potent and toxic, illicit opioid drugs (eg, fentanyl) …

• People who use drugs have an increased risk of death owing to the toxic, unregulated drug
supply.• Providing a safe supply of substances, including opioids such as hydromorphone …

OBJECTIVES Evidence on the perinatal health of mother-infant dyads affected by opioids is
limited. Elevated risks of opioid-related harms for people with opioid use disorder (OUD) …