Catalytic nanoceria are preferentially retained in the rat retina and are not cytotoxic after intravitreal injection

LL Wong, SM Hirst, QN Pye, CM Reilly, S Seal… - PloS one, 2013 - journals.plos.org
Cerium oxide nanoparticles (nanoceria) possess catalytic and regenerative radical
scavenging activities. The ability of nanoceria to maintain cellular redox balance makes …

Picomolar detection of hydrogen peroxide using enzyme-free inorganic nanoparticle-based sensor

CJ Neal, A Gupta, S Barkam, S Saraf, S Das, HJ Cho… - Scientific reports, 2017 - nature.com
A philosophical shift has occurred in the field of biomedical sciences from treatment of late-
stage disease symptoms to early detection and prevention. Ceria nanoparticles (CNPs) …

Nanoparticles for protection of cells from oxidative stress

WM Sigmund, YY Tsai, I Constantinidis… - US Patent App. 12 …, 2010 - Google Patents
The present invention concerns metal oxide semiconductor nanoparticles with free radical
scavenging activity, composi tions comprising such nanoparticles, methods for their use, and …

Redox active cerium oxide nanoparticles and associated methods

P Brenneisen, S Seal, A Karakoti - US Patent 9,585,840, 2017 - Google Patents
Nanoparticles disclosed in the invention comprise a dextran-coated crystalline structure of
cerium oxide wherein tetravalent Ce 4+ predominates over trivalent Ce 3+ and wherein said …

Cerium oxide nanoparticles for treatment and prevention of alzheimer's disease, parkinson's disease, and disorders associated with free radical production and/or …

BA Rzigalinski, N Singh, CA Cohen - US Patent 10,857,178, 2020 - Google Patents
Cerium oxide nanoparticles (CeONP) can be used to treat or prevent neurodegenerative
diseases, including for example Alzheimer's Disease, Parkinson's Disease, Huntington's …

Anti-Inflammatory, Radioprotective, and Longevity Enhancing Capabilities of Cerium Oxide Nanoparticles

BA Rzigalinski, AM Clark - US Patent App. 11/993,260, 2010 - Google Patents
The present invention provides cerium oxide nanoparticles for use both in therapeutic
compositions in vivo and in research in vitro. The cerium oxide nanoparticles are of a known …

Cerium oxide nanoparticles for the treatment and prevention of stroke and cardiovascular disease

BA Rzigalinski, K Hockey, LM Klein, CA Sholar… - US Patent …, 2017 - Google Patents
A method of treating or preventing neurological injury in a subject who has suffered a stroke
is described. The method includes administering a therapeutically effective amount of …

Methods of using cerium oxide nanoparticles to mitigate or protect against radiation injury

Z Vujaskovic, IL Jackson, S Seal, S Das - US Patent 9,415,065, 2016 - Google Patents
Methods of mitigating the effects of radiation exposure or providing a radioprotective effect in
a subject are provided herein. The methods include administering a therapeutically effective …

Treatment of cancer with a combination of radiation, cerium oxide nanoparticles, and a chemotherapeutic agent

C Baker - US Patent 11,389,536, 2022 - Google Patents
The present invention is directed to methods for the treatment of cancer with a combination
of radiation, cerium oxide nanoparticles and at least one chemotherapeutic agent. Cerium …

Methods for treating sepsis

E Blough, N Manne, S Vellaisamy - US Patent 9,669,055, 2017 - Google Patents
Methods for treating sepsis are provided and include the administration an effective amount
of cerium oxide nanoparticles to a subject in need thereof. The sepsis being treated can …