Regulation of development and differentiation by the extracellular matrix Page 1
INTRODUCTION Differentiation is a continuously regulated process and interactions between the …

Endothelial cells of the blood and lymphatic vasculature are polarized cells with luminal
surfaces specialized to interact with inflammatory cells upon the appropriate stimulation; …

Cellular invasion depends on cooperation between adhesive and proteolytic mechanisms.
Evidence is provided that the matrix metalloproteinase MMP-2 can be localized in a …

The extracellular matrix protein vitronectin is recognized as an adhesive substrate by cells
expressing at least one of four known vitronectin receptors: integrins αvβ1, αvβ3, αvβ5 or …

Endothelial cells of blood vessels of the central nervous system (CNS) constitute blood-CNS
barriers. Barrier properties are not intrinsic to these cells; rather they are induced and …

Corresponding aulhor: Klaus T. Preissner, Haemostasis Research Unit, Kerckhoff-Klinik,
MPI, Sprudelhof 11, D-61231 Bad Nauheim, Germany; Tel+ 49-6032-996-719; Fax+ 49 …

Human umbilical vein endothelial cell attachment, spreading and migration on collagen and
vitronectin are mediated by integrins alpha 2 beta 1 and alpha v beta 3, respectively, and …

Each normal organ and pathological condition appear to contain organ-or disease-specific
molecular tags on its vasculature, which constitute a vascular “zip code” system. In vivo …

Osteopontin (OPN) is an extracellular matrix protein that binds to integrin α v β 3. Here we
demonstrate that two other integrins, α v β 1 and α v β 5, are also receptors for OPN. Human …

Osteopontin (OPN) is a secreted adhesive glycoprotein with a functional glycine-arginine-
glycine-aspartate-serine (GRGDS) cell-binding domain. An interesting feature of OPN …