Almost all polymerase II transcripts undergo alternative pre-mRNA splicing. Here, we review
the functions of alternative splicing events that have been experimentally determined. The …

A succession of technological advances over the past decade have enabled researchers to
chart maps of histone modifications and related chromatin structures with increasing …

Background Recent evidence suggests that RNA interaction can regulate the activity and
localization of chromatin-associated proteins. However, it is unknown if these observations …

During evolution segments of homeothermic genomes underwent a GC content increase.
Our analyses reveal that two exon-intron architectures have evolved from an ancestral state …

MicroRNA (miRNA) biogenesis initiates co-transcriptionally, but how the Microprocessor
machinery pinpoints the locations of short precursor miRNA sequences within long flanking …

Pre-messenger RNAs (pre-mRNAs) maturation is initiated cotranscriptionally. It is therefore
conceivable that chromatin-borne information participates in alternative splicing. Here we …

Histones shape chromatin structure and the epigenetic landscape. H1, the most diverse
histone in the human genome, has 11 variants. Due to the high structural similarity between …

Poly (ADP-ribosyl) ation is a posttranslational modification catalyzed by the poly (ADP-
ribose) polymerases (PARPs). These enzymes covalently modify glutamic, aspartic and …

After the generation of DNA double-strand breaks (DSBs), poly (ADP-ribose) polymerase-1
(PARP-1) is one of the first proteins to be recruited and activated through its binding to the …

Missense, nonsense, and translationally silent mutations can inactivate genes by altering
the inclusion of mutant exons in mRNA, but their overall frequency among disease‐causing …