Accumulating evidence shows that cellular and acellular components in tumor
microenvironment (TME) can reprogram tumor initiation, growth, invasion, metastasis, and …

The tumor microenvironment (TME) is a complex and ever-changing “rogue organ”
composed of its own blood supply, lymphatic and nervous systems, stroma, immune cells …

Acidic metabolic waste products accumulate in the tumor microenvironment because of high
metabolic activity and insufficient perfusion. In tumors, the acidity of the interstitial space and …

The high metabolic demand of cancer cells leads to an accumulation of H+ ions in the
tumour microenvironment. The disorganized tumour vasculature prevents an efficient wash …

Abstract Glutamine synthase 2 (GLS2) is a key regulator of glutaminolysis and has been
previously implicated in activities consistent with tumor suppression. Here we generated …

Inflammatory Arthritis is characterized by synovial proliferation, neovascularization and
leukocyte extravasation leading to joint destruction and functional disability. Efficiency of …

Lipid peroxidation is the process by which oxygen combines with lipids to generate lipid
hydroperoxides via intermediate formation of peroxyl radicals. Vitamin E and coenzyme Q …

Cancers undergo sequential changes to proton (H+) concentration and sensing that are
consequences of the disease and facilitate its further progression. The impact of protonation …

Deregulation of angiogenesis–the growth of new blood vessels from an existing vasculature–
is a main driving force in many severe human diseases including cancer. As such, tumor …

Bioenergetic preferences of cancer cells foster tumor acidosis that in turn leads to dramatic
reduction in glycolysis and glucose-derived acetyl-coenzyme A (acetyl-CoA). Here, we show …