In 2005, the first evidence of an allosteric binding site at the CB1R was provided by the
identification of three indoles of the company Organon that were allosteric enhancers of …

The cannabinoid CB1 receptor is a G protein coupled receptor and plays an important role
in many biological processes and physiological functions. A variety of CB1 receptor agonists …

Blockade of cannabinoid type 1 (CB 1)-receptor signaling decreases the rewarding
properties of many drugs of abuse and has been proposed as an anti-addiction strategy …

Undesirable side effects associated with orthosteric agonists/antagonists of cannabinoid 1
receptor (CB1R), a tractable target for treating several pathologies affecting humans, have …

In this work, we explored the molecular framework of the known CB1R allosteric modulator
PSNCBAM-1 with the aim to generate new bioactive analogs and to deepen the structure …

The direct blockade of CB1 cannabinoid receptors produces therapeutic effects as well as
adverse side-effects that limit their clinical potential. CB1 negative allosteric modulators …

The endocannabinoid system interacts with the reward system to modulate responsiveness
to natural reinforcers, as well as drugs of abuse. Previous preclinical studies suggested that …

Abstract Introduction and Objectives: The traditional approach to target a particular receptor
is to design compounds that bind to the same site as the endogenous ligand, the so-called …