Renal tissue hypoperfusion and hypoxia are key elements in the pathophysiology of acute
kidney injury and its progression to chronic kidney disease. Yet, in vivo assessment of renal …

Diabetic nephropathy (DN) is now a leading cause of end‐stage renal disease. In addition,
DN accounts for the increased mortality in type 1 and type 2 diabetes, and then patients …

Established as a method to study anatomic changes, such as renal tumors or atherosclerotic
vascular disease, magnetic resonance imaging (MRI) to interrogate renal function has only …

Background Although chronic hypoxia and fibrosis may be a key to the progression of
chronic kidney disease (CKD), a noninvasive means of measuring these variables is not yet …

Experimentally renal tissue hypoxia appears to play an important role in the pathogenesis of
chronic kidney disease (CKD) and arterial hypertension (AHT). In this study we measured …

Background Animal studies suggest that progression of chronic kidney disease (CKD) is
related to renal hypoxia. With renal blood supply determining oxygen delivery and sodium …

Background The current clinical classification of chronic kidney disease (CKD) is not perfect
and may be overestimating both the prevalence and the risk for progressive disease. Novel …

Increasing HIF activity in the diabetic kidney may possess a novel target for treatment of
DKD by improving kidney oxygen homeostasis. However, HIF-mediated glomerulosclerosis …

Objectives This study was designed to detail the relation between renal T 2* and renal tissue
pO 2 using an integrated approach that combines parametric magnetic resonance imaging …

BOLD-MRI (blood oxygenation-level dependent magnetic resonance imaging) allows non-
invasive measurement of renal tissue oxygenation in humans, without the need for contrast …