Microfluidic technologies and devices for lipid nanoparticle-based RNA delivery
In 2021, mRNA vaccines against COVID-19 were approved by the Food and Drug
Administration. mRNA vaccines are important for preventing severe COVID-19 and returning …
Administration. mRNA vaccines are important for preventing severe COVID-19 and returning …
Microfluidic nanoparticles for drug delivery
Nanoparticles (NPs) have attracted tremendous interest in drug delivery in the past decades.
Microfluidics offers a promising strategy for making NPs for drug delivery due to its capability …
Microfluidics offers a promising strategy for making NPs for drug delivery due to its capability …
[HTML][HTML] Preparation of solid lipid nanoparticles and nanostructured lipid carriers for drug delivery and the effects of preparation parameters of solvent injection method
Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) have emerged as
potential drug delivery systems for various applications that are produced from …
potential drug delivery systems for various applications that are produced from …
Lipid-based nanoparticles for drug/gene delivery: An overview of the production techniques and difficulties encountered in their industrial development
Over the past decade, the therapeutic potential of nanomaterials as novel drug delivery
systems complementing conventional pharmacology has been widely acknowledged …
systems complementing conventional pharmacology has been widely acknowledged …
[HTML][HTML] Intelligent control of nanoparticle synthesis on microfluidic chips with machine learning
X Chen, H Lv - NPG Asia Materials, 2022 - nature.com
Nanoparticles play irreplaceable roles in optoelectronic sensing, medical therapy, material
science, and chemistry due to their unique properties. There are many synthetic pathways …
science, and chemistry due to their unique properties. There are many synthetic pathways …
[HTML][HTML] Quality by Design for enabling RNA platform production processes
RNA-based products have emerged as one of the most promising and strategic
technologies for global vaccination, infectious disease control, and future therapy …
technologies for global vaccination, infectious disease control, and future therapy …
[HTML][HTML] Research advances on the stability of mRNA vaccines
F Cheng, Y Wang, Y Bai, Z Liang, Q Mao, D Liu, X Wu… - Viruses, 2023 - mdpi.com
Compared to other vaccines, the inherent properties of messenger RNA (mRNA) vaccines
and their interaction with lipid nanoparticles make them considerably unstable throughout …
and their interaction with lipid nanoparticles make them considerably unstable throughout …
Lipid nanoparticles optimized for targeting and release of nucleic acid
Y Jia, X Wang, L Li, F Li, J Zhang… - Advanced Materials, 2024 - Wiley Online Library
Lipid nanoparticles (LNPs) are currently the most promising clinical nucleic acids drug
delivery vehicles. LNPs prevent the degradation of cargo nucleic acids during blood …
delivery vehicles. LNPs prevent the degradation of cargo nucleic acids during blood …
[HTML][HTML] Mass production system for RNA-loaded lipid nanoparticles using piling up microfluidic devices
M Maeki, Y Okada, S Uno, K Sugiura, Y Suzuki… - Applied Materials …, 2023 - Elsevier
Microfluidic devices are widely used in lipid nanoparticle (LNP)-based vaccines and
nanomedicine research. These devices should be stiff enough to withstand the high flow …
nanomedicine research. These devices should be stiff enough to withstand the high flow …
[HTML][HTML] Microfluidics for nano-drug delivery systems: from fundamentals to industrialization
H Zhang, J Yang, R Sun, S Han, Z Yang… - Acta Pharmaceutica Sinica …, 2023 - Elsevier
In recent years, owing to the miniaturization of the fluidic environment, microfluidic
technology offers unique opportunities for the implementation of nano drug delivery systems …
technology offers unique opportunities for the implementation of nano drug delivery systems …