Neuroinflammatory process involved in different preclinical models of chemotherapy-induced peripheral neuropathy

G Fumagalli, L Monza, G Cavaletti, R Rigolio… - Frontiers in …, 2021 - frontiersin.org
Peripheral neuropathies are characterized by nerves damage and axonal loss, and they
could be classified in hereditary or acquired forms. Acquired peripheral neuropathies are …

Chemotherapy-induced peripheral neuropathy: What do we know about mechanisms?

VA Carozzi, A Canta, A Chiorazzi - Neuroscience letters, 2015 - Elsevier
Cisplatin, oxaliplatin, paclitaxel, vincristine and bortezomib are some of the most effective
drugs successfully employed (alone or in combinations) as first-line treatment for common …

[HTML][HTML] Nicotinic acetylcholine receptors: Therapeutic targets for novel ligands to treat pain and inflammation

AJ Hone, JM McIntosh - Pharmacological research, 2023 - Elsevier
Nicotinic acetylcholine receptors (nAChRs) have been historically defined as ligand-gated
ion channels and function as such in the central and peripheral nervous systems. Recently …

Anti-inflammatory role of microglial alpha7 nAChRs and its role in neuroprotection

J Egea, I Buendia, E Parada, E Navarro, R Leon… - Biochemical …, 2015 - Elsevier
Nicotinic acetylcholine receptors (nAChRs) are widely distributed throughout the central
nervous system, being expressed in neurons and non-neuronal cells, where they participate …

Oxaliplatin-induced peripheral neuropathy: clinical features, mechanisms, prevention and treatment

L Kang, Y Tian, S Xu, H Chen - Journal of neurology, 2021 - Springer
Oxaliplatin (OXA) is a commonly used platinum-based chemotherapy drug for colorectal
cancer. OXA-induced peripheral neurotoxcity (OIPN) is a comprehensive adverse reaction of …

[HTML][HTML] Platinum-induced neurotoxicity: A review of possible mechanisms

O Kanat, H Ertas, B Caner - World journal of clinical oncology, 2017 - ncbi.nlm.nih.gov
Patients treated with platinum-based chemotherapy frequently experience neurotoxic
symptoms, which may lead to premature discontinuation of therapy. Despite discontinuation …

[HTML][HTML] Immune-mediated processes implicated in chemotherapy-induced peripheral neuropathy

JG Lees, PGS Makker, RS Tonkin, M Abdulla… - European journal of …, 2017 - Elsevier
Chemotherapy-induced peripheral neuropathy (CIPN) and associated neuropathic pain are
challenging complications of cancer treatment. Many of the major classes of …

Targeting strategies for oxaliplatin-induced peripheral neuropathy: clinical syndrome, molecular basis, and drug development

Y Yang, B Zhao, X Gao, J Sun, J Ye, J Li… - Journal of experimental & …, 2021 - Springer
Oxaliplatin (OHP)-induced peripheral neurotoxicity (OIPN) is a severe clinical problem and
potentially permanent side effect of cancer treatment. For the management of OIPN, accurate …

Glial role in oxaliplatin-induced neuropathic pain

LDC Mannelli, A Pacini, L Micheli, A Tani… - Experimental …, 2014 - Elsevier
Oxaliplatin, a platinum-based chemotherapeutic agent, has become a standard treatment for
advanced colorectal cancer. The dose-limiting toxicity of this compound is the development …

Serum neurofilament light chain levels as a biomarker of neuroaxonal injury and severity of oxaliplatin-induced peripheral neuropathy

SH Kim, MK Choi, NY Park, JW Hyun, MY Lee… - Scientific reports, 2020 - nature.com
We set out to determine the usability of serum neurofilament light chain (sNfL), serum glial
fibrillary acidic protein (sGFAP), and retinal parameters by using optical coherence …