Structure, function, and pharmacology of glutamate receptor ion channels

KB Hansen, LP Wollmuth, D Bowie, H Furukawa… - Pharmacological …, 2021 - Elsevier
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Bridging biological and artificial neural networks with emerging neuromorphic devices: fundamentals, progress, and challenges

J Tang, F Yuan, X Shen, Z Wang, M Rao… - Advanced …, 2019 - Wiley Online Library
As the research on artificial intelligence booms, there is broad interest in brain‐inspired
computing using novel neuromorphic devices. The potential of various emerging materials …

Glutamatergic signaling in the central nervous system: ionotropic and metabotropic receptors in concert

A Reiner, J Levitz - Neuron, 2018 - cell.com
Glutamate serves as both the mammalian brain's primary excitatory neurotransmitter and as
a key neuromodulator to control synapse and circuit function over a wide range of spatial …

Calcium permeable-AMPA receptors and excitotoxicity in neurological disorders

C Guo, YY Ma - Frontiers in neural circuits, 2021 - frontiersin.org
Excitotoxicity is one of the primary mechanisms of cell loss in a variety of diseases of the
central and peripheral nervous systems. Other than the previously established signaling …

Novel insights into double-stranded RNA-mediated immunopathology

R de Reuver, J Maelfait - Nature Reviews Immunology, 2024 - nature.com
Recent progress in human and mouse genetics has transformed our understanding of the
molecular mechanisms by which recognition of self double-stranded RNA (self-dsRNA) …

Synaptic memory and CaMKII

RA Nicoll, H Schulman - Physiological reviews, 2023 - journals.physiology.org
Ca2+/calmodulin-dependent protein kinase II (CaMKII) and long-term potentiation (LTP)
were discovered within a decade of each other and have been inextricably intertwined ever …

Transcellular nanoalignment of synaptic function

T Biederer, PS Kaeser, TA Blanpied - Neuron, 2017 - cell.com
At each of the brain's vast number of synapses, the presynaptic nerve terminal, synaptic cleft,
and postsynaptic specialization form a transcellular unit to enable efficient transmission of …

Autoimmune seizures and epilepsy

C Geis, J Planagumà, M Carreño… - The Journal of …, 2019 - Am Soc Clin Investig
The rapid expansion in the number of encephalitis disorders associated with autoantibodies
against neuronal proteins has led to an incremental increase in use of the term “autoimmune …

[HTML][HTML] Neocortex saves energy by reducing coding precision during food scarcity

Z Padamsey, D Katsanevaki, N Dupuy, NL Rochefort - Neuron, 2022 - cell.com
Information processing is energetically expensive. In the mammalian brain, it is unclear how
information coding and energy use are regulated during food scarcity. Using whole-cell …

Merging signaling with structure: functions and mechanisms of plant glutamate receptor ion channels

AA Simon, C Navarro-Retamal… - Annual Review of Plant …, 2023 - annualreviews.org
Plant glutamate receptor-like (GLR) genes encode ion channels with demonstrated roles in
electrical and calcium (Ca2+) signaling. The expansion of the GLR family along the lineage …