Stroke genetics informs drug discovery and risk prediction across ancestries

A Mishra, R Malik, T Hachiya, T Jürgenson, S Namba… - Nature, 2022 - nature.com
Previous genome-wide association studies (GWASs) of stroke—the second leading cause of
death worldwide—were conducted predominantly in populations of European ancestry …

Ischemic stroke and sleep: the linking genetic factors

L Korostovtseva - Cardiology and Therapy, 2021 - Springer
This review summarizes the available data about genetic factors which can link ischemic
stroke and sleep. Sleep patterns (subjective and objective measures) are characterized by …

[HTML][HTML] Venous thromboembolism-related genetic determinant F11 rs4253417 is a potential prognostic factor in ischaemic stroke

V Tavares, J Assis, R Pinto, M Freitas-Silva… - Molecular and Cellular …, 2023 - Elsevier
Ischaemic stroke (IS) and venous thromboembolism (VTE) are two forms of
thromboembolism that, although distinct, seem to share numerous risk factors. Concerning …

The contact system at the crossroads of various key patho-physiological functions: update on present understanding, laboratory exploration and future perspectives

J Amiral, J Seghatchian - Transfusion and Apheresis Science, 2019 - Elsevier
The contact system initiates the intrinsic pathway of coagulation and is started by Factor XII
activation, which then activates prekallicrein to kallicrein and Factor XI to Factor XIa and, in …

Whole-Exome Sequencing in a Family with an Unexplained Tendency for Venous Thromboembolism: Multicomponent Prediction of Low-Frequency Variant …

B Lunghi, N Ziliotto, D Balestra, L Rossi… - International Journal of …, 2023 - mdpi.com
Whole-exome sequencing (WES) in families with an unexplained tendency for venous
thromboembolism (VTE) may favor detection of low-frequency variants in genes with known …

KNG1 mutations (c. 618 T> G and c. 1165C> T) cause disruption of the Cys206-Cys218 disulfide bond and truncation of the D5 domain leading to hereditary high …

X Lv, P Li, Y Gui, C Qin, S Huang, Y Qi, H Chen… - Clinical …, 2025 - Elsevier
Background High molecular weight kininogen (HMWK), encoded by the kininogen-1 (KNG1)
gene, is a multifunctional glycoprotein closely associated with the initiation of blood …

Prospective study of plasma high molecular weight kininogen and prekallikrein and incidence of coronary heart disease, ischemic stroke and heart failure

RR Parikh, AR Folsom, JR Misialek, WD Rosamond… - Thrombosis research, 2019 - Elsevier
Introduction High molecular weight kininogen (HK) and prekallikrein (PK) are proteins in the
kallikrein/kinin system of the coagulation cascade. They play an important role in the contact …

[HTML][HTML] Faktor XI: Ein neues Ziel für die Antikoagulation

XI Faktor - trillium.de
Zusätzlich kann Thrombin aber auch FXI zu FXIa aktivieren [3]. Aus Plättchengranula
freigesetzte Polyphosphate fördern die durch FIIa vermittelte Aktivierung von FXIa massiv …

[PDF][PDF] Mendeliaanse randomisatie

HG de Haan, B Siegerink… - Genetic …, 2019 - scholarlypublications …
Mendeliaanse randomisatie Page 169 CHAPTER 7 Mendeliaanse randomisatie de Haan HG,
Siegerink B, van Hylckama Vlieg A. Ned Tijdschr Geneeskd. 2014; 158: A7547. Page 170 168 …

[PDF][PDF] Genetic determinants of venous thrombosis

HG Haan - J Thromb Haemost, 2016 - scholarlypublications …
Genetic determinants of venous thrombosis Genetic determinants of enous thrombosis Haan,
HG de Citation Haan, HG de.(2020, anuar 8).. Retrie ed from https://hdl. handle. net/1887/82479 …