It is now established that adipose tissue, skeletal muscle, and heart are endocrine organs
and secrete in normal and in pathological conditions several molecules, called, respectively …

Life expectancy of humans has increased continuously up to the present days, but their
health status (healthspan) was not enhanced by similar extent. To decrease enormous …

Ageing is a complex and multifactorial process. For two decades, the Human Ageing
Genomic Resources (HAGR) have aided researchers in the study of various aspects of …

Both life span and health span are influenced by genetic, environmental and lifestyle factors.
With the genetic influence on human life span estimated to be about 20–25%, epigenetic …

The concept of ageing is one that has intrigued mankind since the beginning of time and is
now more important than ever as the incidence of age-related disorders is increasing in our …

Background Ageing is characterized by a decline in cognitive and bodily functions.
Metformin, the most commonly prescribed antidiabetic agent today, has proved to be able to …

In the fission yeast Schizosaccharomyces pombe, the duration of survival in the stationary
phase, termed the chronological lifespan (CLS), is affected by various environmental factors …

Calorie restriction (CR) in the absence of malnutrition exerts a multitude of physiological
benefits with ageing in model organisms and in humans including improvements in vascular …

Aberrant signal transduction downstream of the Ras GTPase has a well-established role in
tumorigenesis. Mutations that result in hyperactivation of Ras are responsible for a third of all …

Myo-Inositol (MI) has been shown to alleviate aging in Caenorhabditis (C). elegans.
However, the mechanism by which MI alleviates aging remains unclear. In this study, we …