The current research paradigm for Huntington's disease is based on participants with overt
clinical phenotypes and does not address its pathophysiology nor the biomarker changes …

Huntington's disease (HD) is a fully penetrant neurodegenerative disease caused by a
dominantly inherited CAG trinucleotide repeat expansion in the huntingtin gene on …

Huntington's disease (HD) is a devastating monogenic neurodegenerative disease
characterized by early, selective pathology in the basal ganglia despite the ubiquitous …

Background Huntington's disease is an autosomal-dominant neurodegenerative disease
caused by CAG trinucleotide repeat expansion in HTT, resulting in a mutant huntingtin …

Huntingtin (HTT) is now a famous protein because an abnormal expansion of a glutamine
stretch (polyQ) in its N-terminal sequence leads to the devastating neurodegenerative …

Pathological perturbations of the brain are rarely confined to a single locus; instead, they
often spread via axonal pathways to influence other regions. Patterns of such disease …

Transcranial magnetic stimulation (TMS) is a powerful tool to probe in vivo brain circuits, as it
allows to assess several cortical properties such as excitability, plasticity and connectivity in …

Neurodegenerative diseases have shown an increasing incidence in the older population in
recent years. A significant amount of research has been conducted to characterize these …

Background Blood biomarkers of neuronal damage could facilitate clinical management of
and therapeutic development for Huntington's disease. We investigated whether …

Background Frontotemporal dementia is a highly heritable neurodegenerative disorder. In
about a third of patients, the disease is caused by autosomal dominant genetic mutations …