Reimagining the status quo: How close are we to rapid sputum-free tuberculosis diagnostics for all?

RR Nathavitharana, AL Garcia-Basteiro, M Ruhwald… - …, 2022 - thelancet.com
Rapid, accurate, sputum-free tests for tuberculosis (TB) triage and confirmation are urgently
needed to close the widening diagnostic gap. We summarise key technologies and review …

Initial immune response after exposure to Mycobacterium tuberculosis or to SARS-COV-2: similarities and differences

A Aiello, S Najafi-Fard, D Goletti - Frontiers in Immunology, 2023 - frontiersin.org
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) and Coronavirus disease-
2019 (COVID-19), whose etiologic agent is severe acute respiratory syndrome coronavirus …

Respiratory Aerosol Emissions from Vocalization: Age and Sex Differences Are Explained by Volume and Exhaled CO2

N Good, KM Fedak, D Goble, A Keisling… - … & Technology Letters, 2021 - ACS Publications
Evidence suggests that airborne transmission of infectious respiratory aerosol plays an
important role for the SARS-CoV-2 virus. This work characterized respiratory aerosol …

Vaccine development against tuberculosis before and after Covid-19

SHE Kaufmann - Frontiers in Immunology, 2023 - frontiersin.org
Coronavirus disease (Covid-19) has not only shaped awareness of the impact of infectious
diseases on global health. It has also provided instructive lessons for better prevention …

Aerosolization of Mycobacterium tuberculosis by Tidal Breathing

R Dinkele, S Gessner, A McKerry… - American Journal of …, 2022 - atsjournals.org
Rationale: Interrupting tuberculosis (TB) transmission requires an improved understanding
of how and when the causative organism, Mycobacterium tuberculosis (Mtb), is aerosolized …

A Mycobacterium tuberculosis fingerprint in human breath allows tuberculosis detection

SF Mosquera-Restrepo, S Zuberogoïtia… - Nature …, 2022 - nature.com
An estimated one-third of tuberculosis (TB) cases go undiagnosed or unreported. Sputum
samples, widely used for TB diagnosis, are inefficient at detecting infection in children and …

Insights into the profile of the human expiratory microbiota and its associations with indoor microbiotas

Y Zhang, F Shen, Y Yang, M Niu, D Chen… - … science & technology, 2022 - ACS Publications
Microorganisms residing in the human respiratory tract can be exhaled, and they constitute a
part of environmental microbiotas. However, the expiratory microbiota community and its …

Aerosolization of viable Mycobacterium tuberculosis bacilli by tuberculosis clinic attendees independent of sputum-Xpert Ultra status

B Patterson, R Dinkele, S Gessner… - Proceedings of the …, 2024 - National Acad Sciences
Potential Mycobacterium tuberculosis (Mtb) transmission during different pulmonary
tuberculosis (TB) disease states is poorly understood. We quantified viable aerosolized Mtb …

Diagnosing tuberculosis: what do new technologies allow us to (not) do?

SM Abdulgader, AO Okunola, G Ndlangalavu… - Respiration, 2022 - karger.com
New tuberculosis (TB) diagnostics are at a crossroads: their development, evaluation, and
implementation is severely damaged by resource diversion due to COVID-19. Yet several …

The Titanic question in TB control: Should we worry about the bummock?

SM Fortune - Proceedings of the National Academy of …, 2024 - National Acad Sciences
In the study of sea ice, the portion of an iceberg that sits below the water is known as the
bummock, counterpart to the hummock, the visible crest of ice. As amateur oceanographers …