Carbohydrates—namely glycans—decorate every cell in the human body and most secreted
proteins. Advances in genomics, glycoproteomics and tools from chemical biology have …

The development of immunotherapy agents has revolutionized the field of oncology. The
only FDA-approved immunotherapeutic approach in breast cancer consists of immune …

The ability to exploit the immune system as a weapon against cancer has revolutionised the
treatment of cancer patients, especially through immune checkpoint inhibitors (ICIs) …

Breast cancer is known as the most common invasive malignancy in women with the highest
mortality rate worldwide. This concerning disease may be presented in situ (relatively easier …

Recent progress in immunobiology has led the way to successful host immunity
enhancement against breast cancer. In triple-negative breast cancer, the combination of …

Triple-negative breast cancer (TNBC) is the subtype of breast cancer with the poorest
outcomes, and is associated with a high risk of relapse and metastasis. The treatment …

Oligosaccharides are ubiquitous in molecular biology and are used for functions ranging
from governing protein folding to intercellular communication. Perhaps paradoxically, the …

Simple Summary Glycosylation is one of the most pivotal post-translational modifications on
all types of biomolecules for the formation of glycoproteins, glycolipids, and glycoRNAs in a …

Cancer remains a leading cause of death worldwide due to the lack of safer and more
effective therapies. Cancer vaccines developed from neoantigens are an emerging strategy …

Part of the broader glycosphingolipid family, gangliosides are composed of a ceramide
bound to a sialic acid-containing glycan chain, and locate at the plasma membrane …