Abstract The Myogenic Regulatory Factors (MRFs) Myf5, MyoD, myogenin and MRF4 are
members of the basic helix-loop-helix family of transcription factors that control the …

We discuss the upstream regulators of myogenesis that lead to the activation of myogenic
determination genes and subsequent differentiation, focusing on the mouse model. Key …

Following their discovery in 1961, it was speculated that satellite cells were dormant
myoblasts, held in reserve until required for skeletal muscle repair. Evidence for this …

Satellite cells are adult myogenic stem cells that repair damaged muscle. The enduring
capacity for muscle regeneration requires efficient satellite cell expansion after injury, their …

Thyroid hormone signalling regulates crucial biological functions, including energy
expenditure, thermogenesis, development and growth. The skeletal muscle is a major target …

Satellite cells are a heterogeneous population of stem and progenitor cells that are required
for the growth, maintenance and regeneration of skeletal muscle. The transcription factors …

Like other subclasses within the PAX transcription factor family, PAX3 and PAX7 play
important roles in the emergence of a number of different tissues during development. PAX3 …

Forkhead box class O family member proteins (FoxOs) are highly conserved transcription
factors with important roles in cellular homeostasis. The four FoxO members in humans …

Myogenic potential, survival and expansion of mammalian muscle progenitors depend on
the myogenic determinants Pax3 and Pax7 embryonically, and Pax7 alone perinatally …

Summary The PI3K-AKT-FoxO pathway is integral to lifespan regulation in lower organisms
and essential for the stability of long-lived cells in mammals. Here, we report the impact of …