Yang and co-workers appeared (Figure 1), 2 and 16 years since their accompanying Accounts article,“Chemical Detoxification of Nerve Agent VX.” 14 Also, organophosphonate …
The number of intoxications with organophosphorus pesticides (OPs) is estimated at some 3 000 000 per year, and the number of deaths and casualties some 300 000 per year. OPs act …
F Worek, H Thiermann, L Szinicz, P Eyer - Biochemical pharmacology, 2004 - Elsevier
The wide-spread use of organophosphorus compounds (OP) as pesticides and the availability of highly toxic OP-type chemical warfare agents (nerve agents) underlines the …
RT Delfino, TS Ribeiro… - Journal of the Brazilian …, 2009 - SciELO Brasil
Chemical warfare agents constitute one of the greatest threats in the modern world. Among them, the neurotoxic agents are of special interest due to their high lethality and danger …
A Saxena, AMG Redman, X Jiang, O Lockridge… - Biochemistry, 1997 - ACS Publications
Amino acid sequence alignments of cholinesterases revealed that 6 of 14 aromatic amino acid residues lining the active center gorge of acetylcholinesterase are replaced by aliphatic …
F Worek, H Thiermann - Pharmacology & therapeutics, 2013 - Elsevier
Poisoning by organophosphorus compounds (OP) still is a major therapeutic problem. Intentional OP pesticide poisoning results in up to 300.000 deaths each year and highly …
BJ Lukey, JA Romano Jr, JA Romano, H Salem… - 2007 - taylorfrancis.com
The first edition of this book, Chemical Warfare Agents: Toxicity at Low Levels, was published just prior to the terrorist attacks of September 11th, 2001. Reflecting a greater …
L Gorecki, J Korabecny, K Musilek, D Malinak… - Archives of …, 2016 - Springer
Irreversible inhibition of acetylcholinesterase (AChE) by organophosphates leads to many failures in living organism and ultimately in death. Organophosphorus compounds …
TT Bachmann, B Leca, F Vilatte, JL Marty… - Biosensors and …, 2000 - Elsevier
Engineered variants of Drosophila melanogaster acetylcholinesterase (AChE) were used as biological receptors of AChE-multisensors for the simultaneous detection and discrimination …