Gliomas are the most common central nervous system tumors. New technologies, including
genetic research and advanced statistical methods, revolutionize the therapeutic approach …

Long-lived species Homo sapiens have evolved robust protection mechanisms against
cancer by repressing telomerase and maintaining short telomeres, thereby delaying the …

Malignant brain tumours are complex ecosystems containing neoplastic and stromal
components that generate adaptive and evolutionarily driven aberrant tissues in the central …

The majority of common variants associated with common diseases, as well as an unknown
proportion of causal mutations for rare diseases, fall in noncoding regions of the genome …

Telomere maintenance via telomerase reactivation is a nearly universal hallmark of cancer
cells which enables replicative immortality. In contrast, telomerase activity is silenced in most …

Glioblastoma ranks among the most lethal of all human cancers. Glioblastomas display
striking cellular heterogeneity, with stem-like glioblastoma stem cells (GSCs) at the apex …

The distribution of telomere length in humans is broad, but it has finite upper and lower
boundaries. Growing evidence shows that there are disease processes that are caused by …

Glioblastoma (GBM) is the most common lethal primary brain cancer in adults. Despite
treatment regimens including surgical resection, radiotherapy, and temozolomide (TMZ) …

The success of precision oncology—which aims to match the right therapies to the right
patients based on molecular status—is predicated on a robust pipeline of molecular targets …

Simple Summary Glioblastoma is the most common malignant primary brain tumor in adults.
Glioblastoma accounts for 2 to 3 cases per 100,000 persons in North America and Europe …